Quantitative ultrasound and dual-energy X-ray absorptiometry in the prediction of fragility fracture in men

Stefano Gonnelli, Chiara Cepollaro, Luigi Gennari, Andrea Montagnani, Carla Caffarelli, Daniela Merlotti, Stefania Rossi, Alice Cadirni, Ranuccio Nuti

Research output: Contribution to journalArticlepeer-review


Fragility fractures in men represent a major health problem, and this prompts a necessity for reliable tools for the identification of men at risk of fracture. In order to assess the ability of dual-energy X-ray absorptiometry (DXA) and quantitative ultrasound (QUS) in the prediction of fracture risk in men and whether their combination might be useful in a clinical setting, we studied 401 men (age range 45-82 years, mean 60.3±12.5), of whom 133 had osteoporotic fractures and 268 did not. In all subjects we measured bone mineral density at the lumbar spine (BMD-LS) and at the femur, calculating thereafter the standard femoral subregions: neck (BMD-FN), total hip (BMD-T), trochanter (BMD-TR), intertrochanter (BMD-ITR), and Ward's triangle (BMD-W), by DXA. We also performed ultrasound parameters at the calcaneus: speed of sound (SOS), broadband ultrasound attenuation (BUA) and Stiffness, by Achilles plus, and at the phalanxes: amplitude dependent speed of sound (AD-SoS) and the parameters of the graphic trace: bone transmission time (BTT), fast wave amplitude (FWA), signal dynamic (SDy) and ultrasound bone profile index (UBPI), by Bone Profiler. All DXA and QUS parameters, apart from FWA, were significantly (P

Original languageEnglish
Pages (from-to)963-968
Number of pages6
JournalOsteoporosis International
Issue number8
Publication statusPublished - Jul 2005


  • Bone mineral density
  • Fragility fractures
  • Men
  • Quantitative ultrasound

ASJC Scopus subject areas

  • Medicine(all)


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