Quantitative ultrasound at the phalanges in a cohort of monozygotic twins of different ages

Giuseppe Guglielmi, Francesca De Terlizzi, Michelangelo Nasuto, Lorenzo Sinibaldi, Francesco Brancati

Research output: Contribution to journalArticlepeer-review


Results: In children AD-SoS and BTT were positively correlated with age (r = 0.91, r = 0.91), height (r = 0.88, r = 0.90) and weight (r = 0.81, r = 0.87); in adults AD-SoS was negatively related to age (r = −0.36), AD-SoS and BTT were positively related to height (r = 0.37, r = 0.58). Absolute value differences between twins for AD-SoS and BTT were significantly higher in adult twins (25.9 ± 21.9 for AD-SoS and 0.08 ± 0.08 for BTT) than in children (14.5 ± 12.4 for AD-SoS and 0.05 ± 0.04 for BTT).

Conclusion: Differentiation in bone tissue quality in twins increases with age, probably reflecting lifestyle, personal habits, likely acting through epigenetic mechanisms.

Purpose: The aim of our study was to evaluate bone quality by quantitative ultrasound (QUS) at the phalanges in 129 monozygotic twin couples, outlining the differences between growing subjects and adults.

Materials and methods: A total of 129 healthy monozygotic twin couples (42 of children under 18 years of age and 87 of adults) were studied by phalangeal QUS, measuring amplitude-dependent speed of sound (AD-SoS) and bone transmission time (BTT). Anthropometric data were also recorded.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalRadiologia Medica
Issue number3
Publication statusPublished - 2015


  • Bone mass regulation
  • Bone tissue
  • Hand phalanges
  • Quantitative ultrasound
  • Twins

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


Dive into the research topics of 'Quantitative ultrasound at the phalanges in a cohort of monozygotic twins of different ages'. Together they form a unique fingerprint.

Cite this