Quantitative ultrasound in the assessment of skeletal status

Giuseppe Guglielmi, Judith Adams, Thomas M. Link

Research output: Contribution to journalArticlepeer-review


Quantitative ultrasound (QUS) is a non-invasive technique for the investigation of bone tissue in several pathologies and clinical conditions, especially in the field of osteoporosis. The versatility of the technique, its low cost and lack of ionising radiation have led to the diffusion of this method worldwide. Several studies have been conducted in the last years to investigate the potential of QUS in multiple areas with promising results; the technique has been applied in the prediction of osteoporotic fractures, in monitoring therapies, in the investigation of secondary osteoporosis, in paediatrics, neonatology and genetics. Our review article gives an overview of the most relevant developments in the field of quantitative ultrasound, both in clinical and in experimental settings.

Original languageEnglish
Pages (from-to)1837-1848
Number of pages12
JournalEuropean Radiology
Issue number8
Publication statusPublished - 2009


  • Amplitude-dependent speed of sound (AD-SoS)
  • Bone quality
  • Broad band ultrasound attenuation (BUA)
  • Osteoporosis
  • Quantitative ultrasound (QUS)
  • Quantitative ultrasound index (QUI)
  • Speed of sound (SoS)
  • Stiffness

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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