Quantitative ultrasound of the hand phalanges in a cohort of monozygotic twins: Influence of genetic and environmental factors

G. Guglielmi, F. Terlizzi, I. Torrente, R. Mingarelli, B. Dallapiccola

Research output: Contribution to journalArticle


Objective: Our objective was to evaluate the similarities and differences in bone mass and structure between pairs of monozygotic twins as measured by means of the quantitative ultrasound (QUS) technique. Design: A cohort of monozygotic twins was measured by QUS of the hand phalanges using the DBM sonic bone profiler (IGEA, Carpi, Italy). The parameters studied were amplitude-dependent speed of sound (AD-SoS), ultrasound bone profile index (UBPI), signal dynamics (SDy) and bone transmission time (BTT). Linear correlation coefficients, multivariate linear analysis and the ANOVA test were used to assess intrapair associations between variables and to determine which factors influence the intrapair differences in QUS variables. Patients: One hundred and six pairs of monozygotic twins were enrolled in the study, 68 females and 38 males in the age range 5 to 71 years. Results: Significant intrapair correlations were obtained in the whole population and separately for males and females, regarding height (r=0.98-0.99, p0.74, p

Original languageEnglish
Pages (from-to)727-735
Number of pages9
JournalSkeletal Radiology
Issue number11
Publication statusPublished - Nov 2005



  • Bone mass regulation
  • Bone tissue
  • Hand phalanges
  • Quantitative ultrasound
  • Twins

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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