Quantitative variation of LINE-1 sequences in five species and three subspecies of the subgenus Mus and in five Robertsonian races of Mus musculus domesticus

Paola Rebuzzini, Riccardo Castiglia, Solomon G. Nergadze, George Mitsainas, Pavel Munclinger, Maurizio Zuccotti, Ernesto Capanna, Carlo Alberto Redi, Silvia Garagna

Research output: Contribution to journalArticle

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Abstract

The quantitative variation of a conserved region of the LINE-1 ORF2 sequence was determined in eight species and subspecies of the subgenus Mus (M. m. domesticus, M. m. musculus, M. m. castaneus, M. spicilegus, M. spretus, M. cervicolor, M. cookii, M. caroli) and five Robertsonian races of M. m. domesticus. No differences in LINE-1 ORF2 content were found between all acrocentric or Robertsonian chromosome races, whereas the quantitative variation of the LINE-1 ORF2 sequences detected among the eight taxa partly matches with the clades into which the subgenus is divided. An accumulation of LINE-1 ORF2 elements likely occurred during the evolution of the subgenus. Within the Asiatic clade, M. cervicolor, cookii, and caroli show a low quantity of LINE-1 sequences, also detected within the Palearctic clade in M. m. castaneus and M. spretus, representing perhaps the ancestral condition within the subgenus. On the other hand, M. m. domesticus, M. m. musculus and M. spicilegus showed a high content of LINE-1 ORF2 sequences. Comparison between the chromosomal hybridization pattern of M. m. domesticus, which possesses the highest content, and M. spicilegus did not show any difference in the LINE-1 ORF2 distribution, suggesting that the quantitative variation of this sequence family did not involve chromosome restructuring or a preferential chromosome accumulation, during the evolution of M. m. domesticus.

Original languageEnglish
Pages (from-to)65-76
Number of pages12
JournalChromosome Research
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2009

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Chromosomes
Long Interspersed Nucleotide Elements

Keywords

  • LINE-1
  • Mus
  • Robertsonian translocation

ASJC Scopus subject areas

  • Genetics

Cite this

Quantitative variation of LINE-1 sequences in five species and three subspecies of the subgenus Mus and in five Robertsonian races of Mus musculus domesticus. / Rebuzzini, Paola; Castiglia, Riccardo; Nergadze, Solomon G.; Mitsainas, George; Munclinger, Pavel; Zuccotti, Maurizio; Capanna, Ernesto; Redi, Carlo Alberto; Garagna, Silvia.

In: Chromosome Research, Vol. 17, No. 1, 01.2009, p. 65-76.

Research output: Contribution to journalArticle

Rebuzzini, Paola ; Castiglia, Riccardo ; Nergadze, Solomon G. ; Mitsainas, George ; Munclinger, Pavel ; Zuccotti, Maurizio ; Capanna, Ernesto ; Redi, Carlo Alberto ; Garagna, Silvia. / Quantitative variation of LINE-1 sequences in five species and three subspecies of the subgenus Mus and in five Robertsonian races of Mus musculus domesticus. In: Chromosome Research. 2009 ; Vol. 17, No. 1. pp. 65-76.
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abstract = "The quantitative variation of a conserved region of the LINE-1 ORF2 sequence was determined in eight species and subspecies of the subgenus Mus (M. m. domesticus, M. m. musculus, M. m. castaneus, M. spicilegus, M. spretus, M. cervicolor, M. cookii, M. caroli) and five Robertsonian races of M. m. domesticus. No differences in LINE-1 ORF2 content were found between all acrocentric or Robertsonian chromosome races, whereas the quantitative variation of the LINE-1 ORF2 sequences detected among the eight taxa partly matches with the clades into which the subgenus is divided. An accumulation of LINE-1 ORF2 elements likely occurred during the evolution of the subgenus. Within the Asiatic clade, M. cervicolor, cookii, and caroli show a low quantity of LINE-1 sequences, also detected within the Palearctic clade in M. m. castaneus and M. spretus, representing perhaps the ancestral condition within the subgenus. On the other hand, M. m. domesticus, M. m. musculus and M. spicilegus showed a high content of LINE-1 ORF2 sequences. Comparison between the chromosomal hybridization pattern of M. m. domesticus, which possesses the highest content, and M. spicilegus did not show any difference in the LINE-1 ORF2 distribution, suggesting that the quantitative variation of this sequence family did not involve chromosome restructuring or a preferential chromosome accumulation, during the evolution of M. m. domesticus.",
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