Abstract
Centre refold: (3R,4S,1′S)-4-Amino-1-(1′-(4-methoxyphenyl) ethyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid (AMMOPC) gives a foldamer with an 8-helix conformation. When it was inserted in the 12-helix foldamer of (3R,4S,1′S)-4-amino-1-(1′-(4-methoxyphenyl)ethyl) -5-oxo-pyrrolidine-3-carboxylic acid (AMOPC), it locally induced formation of an 8-helix conformation (see figure).
Original language | English |
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Pages (from-to) | 12564-12568 |
Number of pages | 5 |
Journal | Chemistry - A European Journal |
Volume | 17 |
Issue number | 45 |
DOIs | |
Publication status | Published - Nov 4 2011 |
Keywords
- conformation analysis
- foldamers
- helical structures
- lactams
- quaternary carbon
ASJC Scopus subject areas
- Chemistry(all)