Quaternary centres as a tool for modulating foldamer conformation

Roberta Galeazzi, Gianluca Martelli, Andrea Mazzanti, Mario Orena, Samuele Rinaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Centre refold: (3R,4S,1′S)-4-Amino-1-(1′-(4-methoxyphenyl) ethyl)-3-methyl-5-oxopyrrolidine-3-carboxylic acid (AMMOPC) gives a foldamer with an 8-helix conformation. When it was inserted in the 12-helix foldamer of (3R,4S,1′S)-4-amino-1-(1′-(4-methoxyphenyl)ethyl) -5-oxo-pyrrolidine-3-carboxylic acid (AMOPC), it locally induced formation of an 8-helix conformation (see figure).

Original languageEnglish
Pages (from-to)12564-12568
Number of pages5
JournalChemistry - A European Journal
Volume17
Issue number45
DOIs
Publication statusPublished - Nov 4 2011

Keywords

  • conformation analysis
  • foldamers
  • helical structures
  • lactams
  • quaternary carbon

ASJC Scopus subject areas

  • Chemistry(all)

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