Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801

Fabio Fumagalli, Raffaella Molteni, Francesco Bedogni, Massimo Gennarelli, Jorge Perez, Giorgio Racagni, Marco A. Riva

Research output: Contribution to journalArticlepeer-review

Abstract

Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.

Original languageEnglish
Pages (from-to)2109-2112
Number of pages4
JournalNeuroReport
Volume15
Issue number13
DOIs
Publication statusPublished - Sep 2004

Keywords

  • Conventional and atypical antipsychotics
  • Haloperidol
  • Neurotrophic factors
  • Quetiapine
  • Rat hippocampus

ASJC Scopus subject areas

  • Neuroscience(all)

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