Abstract
Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.
Original language | English |
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Pages (from-to) | 2109-2112 |
Number of pages | 4 |
Journal | NeuroReport |
Volume | 15 |
Issue number | 13 |
DOIs | |
Publication status | Published - Sep 2004 |
Keywords
- Conventional and atypical antipsychotics
- Haloperidol
- Neurotrophic factors
- Quetiapine
- Rat hippocampus
ASJC Scopus subject areas
- Neuroscience(all)