Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801

Fabio Fumagalli; Raffaella Molteni; Francesco Bedogni; Massimo Gennarelli; Jorge Perez; Giorgio Racagni; Marco A. Riva

doi:10.1097/00001756-200409150-00022

Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801

Fabio Fumagalli, Raffaella Molteni, Francesco Bedogni, Massimo Gennarelli, Jorge Perez, Giorgio Racagni, Marco A. Riva

Research output: Contribution to journal › Article › peer-review

Abstract

Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.

Original language	English
Pages (from-to)	2109-2112
Number of pages	4
Journal	NeuroReport
Volume	15
Issue number	13
DOIs	https://doi.org/10.1097/00001756-200409150-00022
Publication status	Published - Sep 2004

Keywords

Conventional and atypical antipsychotics
Haloperidol
Neurotrophic factors
Quetiapine
Rat hippocampus

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200409150-00022

Cite this

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title = "Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801",

abstract = "Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.",

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AU - Fumagalli, Fabio

AU - Molteni, Raffaella

AU - Bedogni, Francesco

AU - Gennarelli, Massimo

AU - Perez, Jorge

AU - Racagni, Giorgio

AU - Riva, Marco A.

PY - 2004/9

Y1 - 2004/9

N2 - Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.

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KW - Conventional and atypical antipsychotics

KW - Haloperidol

KW - Neurotrophic factors

KW - Quetiapine

KW - Rat hippocampus

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Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801

Abstract

Keywords

ASJC Scopus subject areas

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