Abstract
Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.
| Original language | English |
|---|---|
| Pages (from-to) | 2109-2112 |
| Number of pages | 4 |
| Journal | NeuroReport |
| Volume | 15 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - Sep 2004 |
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Keywords
- Conventional and atypical antipsychotics
- Haloperidol
- Neurotrophic factors
- Quetiapine
- Rat hippocampus
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801. / Fumagalli, Fabio; Molteni, Raffaella; Bedogni, Francesco; Gennarelli, Massimo; Perez, Jorge; Racagni, Giorgio; Riva, Marco A.
In: NeuroReport, Vol. 15, No. 13, 09.2004, p. 2109-2112.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801
AU - Fumagalli, Fabio
AU - Molteni, Raffaella
AU - Bedogni, Francesco
AU - Gennarelli, Massimo
AU - Perez, Jorge
AU - Racagni, Giorgio
AU - Riva, Marco A.
PY - 2004/9
Y1 - 2004/9
N2 - Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.
AB - Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.
KW - Conventional and atypical antipsychotics
KW - Haloperidol
KW - Neurotrophic factors
KW - Quetiapine
KW - Rat hippocampus
UR - http://www.scopus.com/inward/record.url?scp=4644252709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4644252709&partnerID=8YFLogxK
U2 - 10.1097/00001756-200409150-00022
DO - 10.1097/00001756-200409150-00022
M3 - Article
VL - 15
SP - 2109
EP - 2112
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 13
ER -