Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801

Fabio Fumagalli, Raffaella Molteni, Francesco Bedogni, Massimo Gennarelli, Jorge Perez, Giorgio Racagni, Marco A. Riva

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Fibroblast growth factor-2 (FGF-2) and brain-derived neurotrophic factor (BDNF) are trophic factors, widely distributed in the adult brain, whose expression can be modulated by psychoactive drugs. Administration of the atypical antipsychotic quetiapine resulted in a marked elevation of FGF-2 and BDNF mRNA levels in the rat hippocampus, but only under conditions of reduced NMDA receptor activity. These effects were drug-specific, given that they were not observed with the conventional antipsychotic haloperidol; and anatomically defined, since no similar effect was observed in striatum, prefrontal or frontal cortex. These results suggest that quetiapine may promote neuroplasticity via the up-regulation of neurotrophic factors when NMDA-mediated transmission is perturbed.

Original languageEnglish
Pages (from-to)2109-2112
Number of pages4
JournalNeuroReport
Volume15
Issue number13
DOIs
Publication statusPublished - Sep 2004

Fingerprint

Dizocilpine Maleate
Brain-Derived Neurotrophic Factor
Fibroblast Growth Factor 2
Antipsychotic Agents
Hippocampus
Neuronal Plasticity
Psychotropic Drugs
Nerve Growth Factors
Frontal Lobe
Haloperidol
N-Methylaspartate
Prefrontal Cortex
N-Methyl-D-Aspartate Receptors
Up-Regulation
Messenger RNA
Brain
Pharmaceutical Preparations
Quetiapine Fumarate

Keywords

  • Conventional and atypical antipsychotics
  • Haloperidol
  • Neurotrophic factors
  • Quetiapine
  • Rat hippocampus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801. / Fumagalli, Fabio; Molteni, Raffaella; Bedogni, Francesco; Gennarelli, Massimo; Perez, Jorge; Racagni, Giorgio; Riva, Marco A.

In: NeuroReport, Vol. 15, No. 13, 09.2004, p. 2109-2112.

Research output: Contribution to journalArticle

Fumagalli, F, Molteni, R, Bedogni, F, Gennarelli, M, Perez, J, Racagni, G & Riva, MA 2004, 'Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801', NeuroReport, vol. 15, no. 13, pp. 2109-2112. https://doi.org/10.1097/00001756-200409150-00022
Fumagalli, Fabio ; Molteni, Raffaella ; Bedogni, Francesco ; Gennarelli, Massimo ; Perez, Jorge ; Racagni, Giorgio ; Riva, Marco A. / Quetiapine regulates FGF-2 and BDNF expression in the hippocampus of animals treated with MK-801. In: NeuroReport. 2004 ; Vol. 15, No. 13. pp. 2109-2112.
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