INTERFERONE ALFA RICOMBINANTE (ALFA-2B) VERSUS ALFA LINFOBLASTOIDE (ALFA-N1) E BETA NATURALI NELLA TERAPIA DELLE EPATITI CRONICHE CORRELATE AL VIRUS C

Translated title of the contribution: r Alfa-2b IFN vs. Alfa-N1 IFN and H-Beta IFN in chronic hepatitis C therapy

D. Di Palma, L. Iapicco, G. Tarantino, G. Frasci

Research output: Contribution to journalArticlepeer-review

Abstract

A randomized trial was effected to evaluate the therapeutical efficacy of three different IFN types (r-Alfa 2b IFN, Alfa-N1-IFN e Beta-IFN) in long-term therapy (12 months) in 65 pts. (39 males and 26 females; mean age ± SD = 51.9 ± 12.7) afflicted with chronic C hepatitis. Patients (mean Scheuer score: 51.9 ± 12.7) are divided into three groups. In first group (22 pts. = 33.84%) r-Alfa 2b IFN (3 M.U. TIW) was used; second group (23 pts. = 35.38%) was treated with Alfa-N1-IFN (3 M.U. TIW), while Beta-IFN (3 M.U. TIW) was used in third group (20 pts. = 30.38%). Patients which showed normalization in ALT level during or at the end of treatment, were defined 'responders' and if this normalization persisted during follow-up interval of 12 months after the end of therapy, they were defined 'sustained responders'. In the first group 16 'responders' (72.73%) and 13 'sustained responders' (59.09%) were achieved, 11 'responders' (42.82%) and 7 'sustained responders' (30.43%) in the second group and 4 'responders' (20%) and 3 'sustained responders' (15%) in the third group. Both Alfa IFN achieved a significantly higher rate of 'responders' than Beta IFN. Regarding 'sustained responders', rAlfa IFN achieved a significantly higher efficacy than Alfa N1-IFN (p=0.05) and Beta-IFN (p=0.003). After correction for the significative pretreatment variables, multivariate analysis also confirmed these results (logistic analysis), while no pretreatment variables (such as age, Scheuer score, pattern RIBA, Gamma GT value) showed significant effects on the response rate.

Translated title of the contributionr Alfa-2b IFN vs. Alfa-N1 IFN and H-Beta IFN in chronic hepatitis C therapy
Original languageItalian
Pages (from-to)1005-1010
Number of pages6
JournalGiornale di Malattie Infettive e Parassitarie
Volume46
Issue number11
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Parasitology

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