TY - JOUR
T1 - R-ESHAP plus pegfilgrastim as an effective peripheral stem cell mobilization regimen for autologous stem-cell transplantation in patients with relapsed/refractory diffuse large B-cell lymphoma
AU - Montoro, Juan
AU - Andreola, Giovanna
AU - Gardellini, Angelo
AU - Babic, Aleksandra
AU - Negri, Mara
AU - Frungillo, Niccolò
AU - Martinelli, Giovanni
AU - Laszlo, Daniele
PY - 2014
Y1 - 2014
N2 - Stem cell (SC) mobilization is significantly influenced by the mobilization schedule in patients with lymphoma.We evaluated data from 30 patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) undergoing SC mobilization. All received R-ESHAP plus a single dose of pegfilgrastim. All patients collected ≥2×106 CD34+cells/kg, 80% of them at least 5×106 CD34+cells/kg. Adverse effects of the regimen included myelosuppression and neutropenic fever. Herein, our results suggest that R-ESHAP plus pegfilgrastim is a highly effective mobilization strategy in patients affected by DLBCL associated with a low incidence of adverse events.
AB - Stem cell (SC) mobilization is significantly influenced by the mobilization schedule in patients with lymphoma.We evaluated data from 30 patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) undergoing SC mobilization. All received R-ESHAP plus a single dose of pegfilgrastim. All patients collected ≥2×106 CD34+cells/kg, 80% of them at least 5×106 CD34+cells/kg. Adverse effects of the regimen included myelosuppression and neutropenic fever. Herein, our results suggest that R-ESHAP plus pegfilgrastim is a highly effective mobilization strategy in patients affected by DLBCL associated with a low incidence of adverse events.
KW - CD34+ collection
KW - Diffuse large B-cell lymphoma
KW - Pegfilgrastim
KW - R-ESHAP
KW - Stem cell mobilization
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U2 - 10.1016/j.transci.2014.03.006
DO - 10.1016/j.transci.2014.03.006
M3 - Article
C2 - 24751603
AN - SCOPUS:84926119861
VL - 50
SP - 411
EP - 414
JO - Transfusion and Apheresis Science
JF - Transfusion and Apheresis Science
SN - 1473-0502
IS - 3
ER -