R0 resection in the treatment of gastric cancer: Room for improvement

Alberto Biondi, Roberto Persiani, Ferdinando Cananzi, Marco Zoccali, Vincenzo Vigorita, Andrea Tufo, Domenico D'Ugo

Research output: Contribution to journalArticlepeer-review


Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor. In particular, lymphatic metastasis is one of the main predictors of tumor recurrence and survival, and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection. This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage, with lymph node metastasis at diagnosis. All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols, tailoring the extent of resection and the administration of preoperative and postoperative treatment. The goals of all these strategies are to improve prognosis towards the achievement of a curative resection (R0 resection) with minimal morbidity and mortality, and better postoperative quality of life.

Original languageEnglish
Pages (from-to)3358-3370
Number of pages13
JournalWorld Journal of Gastroenterology
Issue number27
Publication statusPublished - 2010


  • Adjuvant therapy
  • Gastric cancer
  • Lymph node dissection
  • Preoperative therapy
  • R0 resection
  • Total gastrectomy

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)


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