TY - JOUR
T1 - R0 resection in the treatment of gastric cancer
T2 - Room for improvement
AU - Biondi, Alberto
AU - Persiani, Roberto
AU - Cananzi, Ferdinando
AU - Zoccali, Marco
AU - Vigorita, Vincenzo
AU - Tufo, Andrea
AU - D'Ugo, Domenico
PY - 2010
Y1 - 2010
N2 - Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor. In particular, lymphatic metastasis is one of the main predictors of tumor recurrence and survival, and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection. This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage, with lymph node metastasis at diagnosis. All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols, tailoring the extent of resection and the administration of preoperative and postoperative treatment. The goals of all these strategies are to improve prognosis towards the achievement of a curative resection (R0 resection) with minimal morbidity and mortality, and better postoperative quality of life.
AB - Gastric carcinoma is one of the most frequent malignancies in the world and its clinical behavior especially depends on the metastatic potential of the tumor. In particular, lymphatic metastasis is one of the main predictors of tumor recurrence and survival, and current pathological staging systems reflect the concept that lymphatic spread is the most relevant prognostic factor in patients undergoing curative resection. This is compounded by the observation that two-thirds of gastric cancer in the Western world presents at an advanced stage, with lymph node metastasis at diagnosis. All current therapeutic efforts in gastric cancer are directed toward individualization of therapeutic protocols, tailoring the extent of resection and the administration of preoperative and postoperative treatment. The goals of all these strategies are to improve prognosis towards the achievement of a curative resection (R0 resection) with minimal morbidity and mortality, and better postoperative quality of life.
KW - Adjuvant therapy
KW - Gastric cancer
KW - Lymph node dissection
KW - Preoperative therapy
KW - R0 resection
KW - Total gastrectomy
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U2 - 10.3748/wjg.v16.i27.3358
DO - 10.3748/wjg.v16.i27.3358
M3 - Article
C2 - 20632437
AN - SCOPUS:77954844946
VL - 16
SP - 3358
EP - 3370
JO - World Journal of Gastroenterology
JF - World Journal of Gastroenterology
SN - 1007-9327
IS - 27
ER -