RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions

Patrizia D'Adamo, Michela Masetti, Veronica Bianchi, Lorenzo Morè, Maria Lidia Mignogna, Maila Giannandrea, Silvia Gatti

Research output: Contribution to journalArticle

Abstract

A RAS-related class of small monomeric G proteins, the RAB GTPases, is emerging as of key biological importance in compartment specific directional control of vesicles formation, transport and fusion. Thanks to human genetic observation and to the consequent dedicated biochemical work, substantial progress has been made on the understanding of the role played by RAB GTPases and their effector proteins on neuronal development and the shaping of cognitive functions. This review is highlighting these initial elements to broaden the current scope of research on developmental cognitive deficits and take the point of view of RAB GTPases control on membrane transport in neurons and astrocytes.

Original languageEnglish
Pages (from-to)302-314
Number of pages13
JournalNeuroscience and Biobehavioral Reviews
Volume46
Issue numberP2
DOIs
Publication statusPublished - Oct 1 2014

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Keywords

  • Brain development
  • G proteins
  • GDI1
  • GTPase
  • Intellectual disability
  • RAB

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Neuropsychology and Physiological Psychology
  • Medicine(all)

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