RAB39A: a Rab small GTPase with a prominent role in cancer stemness

Tokuhiro Chano, Sofia Avnet

Research output: Contribution to journalArticle

Abstract

RAB39A is a Rab small GTPase that localizes at distinct subcellular compartments and regulates intracellular membrane trafficking pathways in vertebrate cells. RAB39A interacts with various molecules and modulates vesicular trafficking that regulates multiple biological pathways such as neuronal differentiation and/or autophagy. Among these pathways are Hippo and Notch signalings, microtubular organization, and mitophagy/autophagy. Although RAB39A has never been studied in cancer biology, it has been recently shown to promote cancer stemness and tumorigenesis. Molecular pathways regulated by RAB39A are transcriptionally maintained by the formation of molecular complex with RXRB, NCOR, and HDAC that also contribute to cancer stemness. In this review, we provide current knowledge on the oncogenic function of RAB39A, and summarize the effect of different microenvironments on RAB39A activity and subcellular localization in cancer cells.

Original languageEnglish
Pages (from-to)9-14
Number of pages6
JournalJournal of Biochemistry
Volume164
Issue number1
DOIs
Publication statusPublished - Apr 10 2018

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rab GTP-Binding Proteins
Monomeric GTP-Binding Proteins
Cells
Membranes
Molecules
Autophagy
Neoplasms
Mitochondrial Degradation
Intracellular Membranes
Vertebrates
Carcinogenesis

Keywords

  • cancer stemness
  • membrane trafficking
  • oncogenic mutation
  • RAB39A
  • Rab small GTPase

Cite this

RAB39A: a Rab small GTPase with a prominent role in cancer stemness. / Chano, Tokuhiro; Avnet, Sofia.

In: Journal of Biochemistry, Vol. 164, No. 1, 10.04.2018, p. 9-14.

Research output: Contribution to journalArticle

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