RAC1/P38 MAPK signaling pathway controls β1 integrin-induced interleukin-8 production in human natural killer cells

Fabrizio Mainiero, Alessandra Soriani, Raffaele Strippoli, Jordan Jacobelli, Angela Gismondi, Mario Piccoli, Luigi Frati, Angela Santoni

Research output: Contribution to journalArticlepeer-review

Abstract

The MAP kinase (MAPK) p38 plays a key role in regulating inflammatory responses. Here, we demonstrate that β1 integrin ligation on human NK cells results in the activation of the p38 MAPK signaling pathway, which is required for integrin-triggered IL-8 production. In addition, we identified some of the upstream events accompanying the β1 integrin-mediated p38 MAPK activation, namely, the activation of the Rac guanine nucleotide exchange factor (GEF) p95 Vav, the small G protein Rac1, and the cytoplasmic kinases Pak1 and MKK3. Finally, we provide direct evidence that p95 Vav and Rac control the activation of p38 MAPK triggered by β1 integrins.

Original languageEnglish
Pages (from-to)7-16
Number of pages10
JournalImmunity
Volume12
Issue number1
Publication statusPublished - Jan 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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