The MAP kinase (MAPK) p38 plays a key role in regulating inflammatory responses. Here, we demonstrate that β1 integrin ligation on human NK cells results in the activation of the p38 MAPK signaling pathway, which is required for integrin-triggered IL-8 production. In addition, we identified some of the upstream events accompanying the β1 integrin-mediated p38 MAPK activation, namely, the activation of the Rac guanine nucleotide exchange factor (GEF) p95 Vav, the small G protein Rac1, and the cytoplasmic kinases Pak1 and MKK3. Finally, we provide direct evidence that p95 Vav and Rac control the activation of p38 MAPK triggered by β1 integrins.
|Number of pages||10|
|Publication status||Published - Jan 2000|
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases