Racial factors and the risk of chronic pancreatitis

Albert B. Lowenfels, Patrick Maisonneuve, Harish Grover, Eric Gerber, Mark A. Korsten, Maria Teresa Antunes, Antonio Marques, C. S. Pitchumoni

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: It is unclear why some alcohol abusers develop alcoholic cirrhosis whereas others contract chronic pancreatitis. The aim of this study was to examine the importance of race as a risk factor for the development of chronic pancreatitis. METHODS: We compared the racial status of 1883 patients discharged with a first-listed diagnosis of two diseases strongly related to alcohol abuse: 433 patients with chronic pancreatitis (ICD 5771) and 1450 patients with alcoholic cirrhosis (ICD 5712). Information came from discharge statistics maintained by two acute care hospitals in New York City and one acute care hospital in Lisbon, Portugal. The study period included the years 1989-1996 in the US and 1989-1994 in Portugal. RESULTS: A total of 215 (50%) of the 433 chronic pancreatitis patients were black compared with 333 (23%) of the 1450 patients with alcoholic cirrhosis. When adjusted for sex and hospital site, patients with pancreatitis were significantly more likely to be black than patients with cirrhosis (odds ratio 2.5, 95% confidence interval 1.9-3.2, p <0.001). CONCLUSIONS: In comparison with white patients, black patients are two to three times more likely to be hospitalized for chronic pancreatitis than alcoholic cirrhosis. This highly significant (p <0.001) difference was observed in both men and women: in three different hospitals, and in two different countries. The explanation is unknown, but could be related to racial differences in diet, type or quantity of alcohol consumption, smoking, or ability to detoxify substances harmful to the liver or pancreas.

Original languageEnglish
Pages (from-to)790-794
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume94
Issue number3
DOIs
Publication statusPublished - Mar 1999

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Chronic Pancreatitis
Alcoholic Liver Cirrhosis
Portugal
Aptitude
Contracts
Alcohol Drinking
Pancreatitis
Alcoholism
Pancreas
Fibrosis
Smoking
Odds Ratio
Alcohols
Confidence Intervals
Diet
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Lowenfels, A. B., Maisonneuve, P., Grover, H., Gerber, E., Korsten, M. A., Antunes, M. T., ... Pitchumoni, C. S. (1999). Racial factors and the risk of chronic pancreatitis. American Journal of Gastroenterology, 94(3), 790-794. https://doi.org/10.1016/S0002-9270(99)00007-6

Racial factors and the risk of chronic pancreatitis. / Lowenfels, Albert B.; Maisonneuve, Patrick; Grover, Harish; Gerber, Eric; Korsten, Mark A.; Antunes, Maria Teresa; Marques, Antonio; Pitchumoni, C. S.

In: American Journal of Gastroenterology, Vol. 94, No. 3, 03.1999, p. 790-794.

Research output: Contribution to journalArticle

Lowenfels, AB, Maisonneuve, P, Grover, H, Gerber, E, Korsten, MA, Antunes, MT, Marques, A & Pitchumoni, CS 1999, 'Racial factors and the risk of chronic pancreatitis', American Journal of Gastroenterology, vol. 94, no. 3, pp. 790-794. https://doi.org/10.1016/S0002-9270(99)00007-6
Lowenfels, Albert B. ; Maisonneuve, Patrick ; Grover, Harish ; Gerber, Eric ; Korsten, Mark A. ; Antunes, Maria Teresa ; Marques, Antonio ; Pitchumoni, C. S. / Racial factors and the risk of chronic pancreatitis. In: American Journal of Gastroenterology. 1999 ; Vol. 94, No. 3. pp. 790-794.
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