Radial maze performance and open-field behaviours in aged C57BL/6 mice: Further evidence for preserved cognitive abilities during senescence

Martine Ammassari-Teule, Sandro Fagioli, Clelia Rossi-Arnaud

Research output: Contribution to journalArticle

Abstract

C57BL/6 mice, aged 2 or 24 months, were tested in a radial maze and observed for an 8-min period, repeated on 3 consecutive days, in an open-field situation with a novel object. In the eight-arm maze, the number of unrepeated path choices made by old mice does not significantly increase with training, whereas it does in young mice. Older animals also take significantly longer to solve the task but the two age groups do not differ with respect to how many paths they run before making the first error or in the strategies used to solve the task. In the open-field situation, the two age groups differ with regard to grooming and rearing behaviour, while in the novelty situation, older animal show a higher level of locomotor activity, perform less freezing, and interact more with the novel object. Habituation curves for all parameters, except grooming in the open field, do not differ between the two groups, thus indicating that this form of nonassociative learning does not vary substantially with increasing age. Results are discussed in terms of preserved cognitive abilities during senescence in that strain.

Original languageEnglish
Pages (from-to)341-345
Number of pages5
JournalPhysiology and Behavior
Volume55
Issue number2
DOIs
Publication statusPublished - 1994

Fingerprint

Grooming
Aptitude
Inbred C57BL Mouse
Age Groups
Locomotion
Freezing
Learning

Keywords

  • Aging
  • C57BL/6 mice
  • Maze learning
  • Novelty
  • Open field

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Radial maze performance and open-field behaviours in aged C57BL/6 mice : Further evidence for preserved cognitive abilities during senescence. / Ammassari-Teule, Martine; Fagioli, Sandro; Rossi-Arnaud, Clelia.

In: Physiology and Behavior, Vol. 55, No. 2, 1994, p. 341-345.

Research output: Contribution to journalArticle

Ammassari-Teule, Martine ; Fagioli, Sandro ; Rossi-Arnaud, Clelia. / Radial maze performance and open-field behaviours in aged C57BL/6 mice : Further evidence for preserved cognitive abilities during senescence. In: Physiology and Behavior. 1994 ; Vol. 55, No. 2. pp. 341-345.
@article{35e8aa5376dd4659be3a6d73c43ea3da,
title = "Radial maze performance and open-field behaviours in aged C57BL/6 mice: Further evidence for preserved cognitive abilities during senescence",
abstract = "C57BL/6 mice, aged 2 or 24 months, were tested in a radial maze and observed for an 8-min period, repeated on 3 consecutive days, in an open-field situation with a novel object. In the eight-arm maze, the number of unrepeated path choices made by old mice does not significantly increase with training, whereas it does in young mice. Older animals also take significantly longer to solve the task but the two age groups do not differ with respect to how many paths they run before making the first error or in the strategies used to solve the task. In the open-field situation, the two age groups differ with regard to grooming and rearing behaviour, while in the novelty situation, older animal show a higher level of locomotor activity, perform less freezing, and interact more with the novel object. Habituation curves for all parameters, except grooming in the open field, do not differ between the two groups, thus indicating that this form of nonassociative learning does not vary substantially with increasing age. Results are discussed in terms of preserved cognitive abilities during senescence in that strain.",
keywords = "Aging, C57BL/6 mice, Maze learning, Novelty, Open field",
author = "Martine Ammassari-Teule and Sandro Fagioli and Clelia Rossi-Arnaud",
year = "1994",
doi = "10.1016/0031-9384(94)90144-9",
language = "English",
volume = "55",
pages = "341--345",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Radial maze performance and open-field behaviours in aged C57BL/6 mice

T2 - Further evidence for preserved cognitive abilities during senescence

AU - Ammassari-Teule, Martine

AU - Fagioli, Sandro

AU - Rossi-Arnaud, Clelia

PY - 1994

Y1 - 1994

N2 - C57BL/6 mice, aged 2 or 24 months, were tested in a radial maze and observed for an 8-min period, repeated on 3 consecutive days, in an open-field situation with a novel object. In the eight-arm maze, the number of unrepeated path choices made by old mice does not significantly increase with training, whereas it does in young mice. Older animals also take significantly longer to solve the task but the two age groups do not differ with respect to how many paths they run before making the first error or in the strategies used to solve the task. In the open-field situation, the two age groups differ with regard to grooming and rearing behaviour, while in the novelty situation, older animal show a higher level of locomotor activity, perform less freezing, and interact more with the novel object. Habituation curves for all parameters, except grooming in the open field, do not differ between the two groups, thus indicating that this form of nonassociative learning does not vary substantially with increasing age. Results are discussed in terms of preserved cognitive abilities during senescence in that strain.

AB - C57BL/6 mice, aged 2 or 24 months, were tested in a radial maze and observed for an 8-min period, repeated on 3 consecutive days, in an open-field situation with a novel object. In the eight-arm maze, the number of unrepeated path choices made by old mice does not significantly increase with training, whereas it does in young mice. Older animals also take significantly longer to solve the task but the two age groups do not differ with respect to how many paths they run before making the first error or in the strategies used to solve the task. In the open-field situation, the two age groups differ with regard to grooming and rearing behaviour, while in the novelty situation, older animal show a higher level of locomotor activity, perform less freezing, and interact more with the novel object. Habituation curves for all parameters, except grooming in the open field, do not differ between the two groups, thus indicating that this form of nonassociative learning does not vary substantially with increasing age. Results are discussed in terms of preserved cognitive abilities during senescence in that strain.

KW - Aging

KW - C57BL/6 mice

KW - Maze learning

KW - Novelty

KW - Open field

UR - http://www.scopus.com/inward/record.url?scp=0028045012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028045012&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(94)90144-9

DO - 10.1016/0031-9384(94)90144-9

M3 - Article

C2 - 8153176

AN - SCOPUS:0028045012

VL - 55

SP - 341

EP - 345

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 2

ER -