TY - JOUR
T1 - Radiation effective dose assessment of [51Mn]- and [52Mn]-chloride
AU - De Nardo, Laura
AU - Ferro-Flores, Guillermina
AU - Bolzati, Cristina
AU - Esposito, Juan
AU - Meléndez-Alafort, Laura
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019/11
Y1 - 2019/11
N2 - In order to establish the potential of [51/52Mn]Cl2 as safe PET brain tracers, the radiation effective dose (ED) of [51Mn]- and [52Mn]-chloride has been assessed by using biokinetic models in anthropomorphic phantoms. Results showed that [52Mn]-chloride releases one hundred thirty times more radiation dose (ED = 1.35 mSv/MBq) than [51Mn]-chloride (ED = 1.02E-02 mSv/MBq). Although the maximum positron energy of 52Mn allows a PET image resolution similar to that of 18F, activities below 15 MBq should be administered.
AB - In order to establish the potential of [51/52Mn]Cl2 as safe PET brain tracers, the radiation effective dose (ED) of [51Mn]- and [52Mn]-chloride has been assessed by using biokinetic models in anthropomorphic phantoms. Results showed that [52Mn]-chloride releases one hundred thirty times more radiation dose (ED = 1.35 mSv/MBq) than [51Mn]-chloride (ED = 1.02E-02 mSv/MBq). Although the maximum positron energy of 52Mn allows a PET image resolution similar to that of 18F, activities below 15 MBq should be administered.
U2 - 10.1016/j.apradiso.2019.108805
DO - 10.1016/j.apradiso.2019.108805
M3 - Article
C2 - 31382087
VL - 153
SP - 1
EP - 6
JO - Applied Radiation and Isotopes
JF - Applied Radiation and Isotopes
SN - 0969-8043
M1 - 108805
ER -