Radiation effective dose assessment of [51Mn]- and [52Mn]-chloride

Laura De Nardo, Guillermina Ferro-Flores, Cristina Bolzati, Juan Esposito, Laura Meléndez-Alafort

Research output: Contribution to journalArticlepeer-review


In order to establish the potential of [51/52Mn]Cl2 as safe PET brain tracers, the radiation effective dose (ED) of [51Mn]- and [52Mn]-chloride has been assessed by using biokinetic models in anthropomorphic phantoms. Results showed that [52Mn]-chloride releases one hundred thirty times more radiation dose (ED = 1.35 mSv/MBq) than [51Mn]-chloride (ED = 1.02E-02 mSv/MBq). Although the maximum positron energy of 52Mn allows a PET image resolution similar to that of 18F, activities below 15 MBq should be administered.

Original languageEnglish
Article number108805
Pages (from-to)1-6
Number of pages6
JournalApplied Radiation and Isotopes
Publication statusPublished - Nov 2019


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