Radiation Induced Brain Aneurysms: Institutional Experience and State of Art in the Contemporary Literature

Alessandro Pesce, Mauro Palmieri, Giuseppa Zancana, Maurizio Salvati, Antonio Santoro, Antonino Raco, Alessandro Frati

Research output: Contribution to journalReview articlepeer-review


BACKGROUND: Brain aneurysms (BA) represent the most common intracranial vascular condition, with an overall incidence of 1-2%. Among the described common causes of their initial formation and growth the role of radiation therapy (RT) has been described in seldom reports. The aim of the present study is to report the most relevant features of BA related to a previous cranial RT.

METHODS: Data deriving from 1 patient treated for RT induced BA in our Institution have been added to other 66 BA retrieved from the current Literature. The following parameters have been evaluated: Age, Sex, Location, Primary Lesion, Clinical Presentation, Dosage/amount of Radiation delivered, type of treatment for the BA, Dimension, Morphology, eventual Chemotherapy, Comorbidities, Risk Factors, Number of BA.

RESULTS: The most commonly involved vessel was ICA (34%). In general, the anterior circulation disclosed a higher vulnerability in respect to the posterior circulation and MCA (56,7%). An average latency between RT and the first imaging disclosing the BA was averagely of 9.01±6.85 years. Vessels coursing in the PCF disclosed a significant univariate association to lower X-Ray dosages (p=.014) in respect to the other locations. No statistically significant correlation between the continuous variables Age, Latency of BA appearance, RT delivered dose and dimension of the BA was disclosed.

CONCLUSIONS: An apparent higher fragility of the vascular structures of the PCF was statistically outlined, the XR dosage, the primary condition target of the RT, the age of the patients, no statistically significant correlation was outlined. Biological factors could play a significant role.

Original languageEnglish
JournalWorld Neurosurg.
Publication statusE-pub ahead of print - Oct 9 2019

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