Abstract
We report a case of glioblastoma (GBM) occurring 8 years after radiation therapy for a medulloblastoma. A 15-year-old boy underwent surgery and radiotherapy for a medulloblastoma and 8 years later he developed a second tumor at the same site. The second lesion showed different histological and molecular features, was diagnosed as a glioblastoma and fulfilled the criteria of radiation-induced neoplasm. Mutational analysis of the p53 gene showed a C to G transition at codon 176 in tumor DNA. LOH was detected at 17p and 19q. The tumor also showed O6-methylguanine-DNA methyl-transferase (MGMT) promoter methylation and no amplification of EGF receptor. In conclusion, the radiation-induced MGMT hyper-methylation and p53 mutations may have a role in the development of a subgroup of radio-induced glioma (RIG), suggesting that these molecular alterations directly cooperate in the genesis of the post-irradiation GBM. Moreover RIGs seem to be a heterogeneous group of tumors that may resemble either primary or secondary GBM.
Original language | English |
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Pages (from-to) | 633-639 |
Number of pages | 7 |
Journal | Neuropathology |
Volume | 28 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2008 |
Keywords
- Loss of heterozygosity
- Medulloblastoma
- MGMT
- p53
- Radiation-induced glioblastoma
ASJC Scopus subject areas
- Clinical Neurology
- Pathology and Forensic Medicine