Radiation-induced glioblastoma in a medulloblastoma patient: A case report with molecular features

Marco Gessi, Emanuela Maderna, Sara Guzzetti, Graziella Cefalo, Maura Massimino, Carlo L. Solero, Gaetano Finocchiaro, Bianca Pollo

Research output: Contribution to journalArticlepeer-review

Abstract

We report a case of glioblastoma (GBM) occurring 8 years after radiation therapy for a medulloblastoma. A 15-year-old boy underwent surgery and radiotherapy for a medulloblastoma and 8 years later he developed a second tumor at the same site. The second lesion showed different histological and molecular features, was diagnosed as a glioblastoma and fulfilled the criteria of radiation-induced neoplasm. Mutational analysis of the p53 gene showed a C to G transition at codon 176 in tumor DNA. LOH was detected at 17p and 19q. The tumor also showed O6-methylguanine-DNA methyl-transferase (MGMT) promoter methylation and no amplification of EGF receptor. In conclusion, the radiation-induced MGMT hyper-methylation and p53 mutations may have a role in the development of a subgroup of radio-induced glioma (RIG), suggesting that these molecular alterations directly cooperate in the genesis of the post-irradiation GBM. Moreover RIGs seem to be a heterogeneous group of tumors that may resemble either primary or secondary GBM.

Original languageEnglish
Pages (from-to)633-639
Number of pages7
JournalNeuropathology
Volume28
Issue number6
DOIs
Publication statusPublished - Dec 2008

Keywords

  • Loss of heterozygosity
  • Medulloblastoma
  • MGMT
  • p53
  • Radiation-induced glioblastoma

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine

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