Radiation-induced osteosarcoma arising 20 years after the treatment of Ewing's sarcoma

Alessandra Longhi, Enza Barbieri, Nicola Fabbri, Michele Macchiagodena, Leonardo Favale, Cataldo Lippo, Nicola Salducca, Gaetano Bacci

Research output: Contribution to journalArticlepeer-review


We report the case of a 17 years old female with a Ewing's sarcoma of the left femur treated with limb sparing surgery followed by local radiotherapy of 45 Gy and adjuvant chemotherapy with vincristine, doxorubicine, cyclophosphamide actinomycin D. The patient received neoadjuvant chemotherapy for osteosarcoma and a left femur resection with endoprosthesis replacement. The patient is alive and free of disease 4 years after the treatment of this second malignant neoplasm (SMN). This case shows that radioinduced SMN can occurr with relatively low doses of RT (

Original languageEnglish
Pages (from-to)569-572
Number of pages4
Issue number5
Publication statusPublished - Sep 2003


  • Ewing's sarcoma
  • Late side effects
  • Post-radiation osteosarcoma

ASJC Scopus subject areas

  • Cancer Research


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