Radiation-induced sarcomas

Andreas F. Mavrogenis, Andrea Angelini, Elisa Pala, Teresa Calabrò, Giuseppe Bianchi, Roberto Casadei, Pietro Ruggieri

Research output: Contribution to journalArticlepeer-review


Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.

Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalJournal of Long-Term Effects of Medical Implants
Issue number3
Publication statusPublished - 2011


  • Bone sarcomas
  • Radiation therapy
  • Soft-tissue sarcomas

ASJC Scopus subject areas

  • Biomedical Engineering
  • Dentistry(all)


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