Radiation-induced sarcomas

Andreas F. Mavrogenis; Andrea Angelini; Elisa Pala; Teresa Calabrò; Giuseppe Bianchi; Roberto Casadei; Pietro Ruggieri

Radiation-induced sarcomas

Andreas F. Mavrogenis, Andrea Angelini, Elisa Pala, Teresa Calabrò, Giuseppe Bianchi, Roberto Casadei, Pietro Ruggieri

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.

Original language	English
Pages (from-to)	233-240
Number of pages	8
Journal	Journal of Long-Term Effects of Medical Implants
Volume	21
Issue number	3
Publication status	Published - 2011

Keywords

Bone sarcomas
Radiation therapy
Soft-tissue sarcomas

ASJC Scopus subject areas

Biomedical Engineering
Dentistry(all)

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abstract = "Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.",

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pages = "233--240",

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T1 - Radiation-induced sarcomas

AU - Mavrogenis, Andreas F.

AU - Angelini, Andrea

AU - Pala, Elisa

AU - Calabrò, Teresa

AU - Bianchi, Giuseppe

AU - Casadei, Roberto

AU - Ruggieri, Pietro

PY - 2011

Y1 - 2011

N2 - Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.

AB - Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.

KW - Bone sarcomas

KW - Radiation therapy

KW - Soft-tissue sarcomas

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AN - SCOPUS:83155192569

VL - 21

SP - 233

EP - 240

JO - Journal of Long-Term Effects of Medical Implants

JF - Journal of Long-Term Effects of Medical Implants

SN - 1050-6934

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