Abstract
Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.
| Original language | English |
|---|---|
| Pages (from-to) | 233-240 |
| Number of pages | 8 |
| Journal | Journal of Long-Term Effects of Medical Implants |
| Volume | 21 |
| Issue number | 3 |
| Publication status | Published - 2011 |
Fingerprint
Keywords
- Bone sarcomas
- Radiation therapy
- Soft-tissue sarcomas
ASJC Scopus subject areas
- Biomedical Engineering
- Dentistry(all)
Cite this
Radiation-induced sarcomas. / Mavrogenis, Andreas F.; Angelini, Andrea; Pala, Elisa; Calabrò, Teresa; Bianchi, Giuseppe; Casadei, Roberto; Ruggieri, Pietro.
In: Journal of Long-Term Effects of Medical Implants, Vol. 21, No. 3, 2011, p. 233-240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiation-induced sarcomas
AU - Mavrogenis, Andreas F.
AU - Angelini, Andrea
AU - Pala, Elisa
AU - Calabrò, Teresa
AU - Bianchi, Giuseppe
AU - Casadei, Roberto
AU - Ruggieri, Pietro
PY - 2011
Y1 - 2011
N2 - Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.
AB - Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.
KW - Bone sarcomas
KW - Radiation therapy
KW - Soft-tissue sarcomas
UR - http://www.scopus.com/inward/record.url?scp=83155192569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=83155192569&partnerID=8YFLogxK
M3 - Article
C2 - 22150356
AN - SCOPUS:83155192569
VL - 21
SP - 233
EP - 240
JO - Journal of Long-Term Effects of Medical Implants
JF - Journal of Long-Term Effects of Medical Implants
SN - 1050-6934
IS - 3
ER -