Abstract
Radiation recall dermatitis is one of the skin sequelae that may affect oncology patients. It occurs in a previously irradiated field, when subsequent chemotherapy is given. The eruption may be elicited by chemotherapy, even several months after radiotherapy. Its mechanism is poorly understood, and the histopathologic findings have received, to date, only sketchy descriptions. A 55-year-old male affected by multiple myeloma received radiation therapy both on his left coxofemoral area, and lumbar region (D11-L1). After cyclophosphamide administration, he developed 2 well defined square-shaped, infiltrated erythematoviolaceous plaques in the prior irradiated fields. Histopathologic findings revealed a diffusely fibrosclerosing process, involving deep dermis, hypodermis, as well as the underlying muscle, while sparing the epidermis and superficial-mid dermis. Histopathology was indistinguishable from deep radio-dermatitis, panniculitis, and myositis. This is the first case providing clear evidence of the causative role of cyclophosphamide in inducing a cutaneous and subcutaneous radiation recall reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 213-216 |
| Number of pages | 4 |
| Journal | American Journal of Dermatopathology |
| Volume | 26 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2004 |
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Keywords
- Cyclophosphamide
- Histopathologic findings
- Myositis
- Panniculitis
- Radiation recall dermatitis
ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine
Cite this
Radiation recall dermatitis, panniculitis, and myositis following cyclophosphamide therapy : Histopathologic findings of a patient affected by multiple myeloma. / Borroni, Giovanni; Vassallo, Camilla; Brazzelli, Valeria; Martinoli, Sara; Ardigò, Marco; Alessandrino, Paolo Emilio; Borroni, Riccardo Giovanni; Franchini, Pietro.
In: American Journal of Dermatopathology, Vol. 26, No. 3, 06.2004, p. 213-216.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiation recall dermatitis, panniculitis, and myositis following cyclophosphamide therapy
T2 - Histopathologic findings of a patient affected by multiple myeloma
AU - Borroni, Giovanni
AU - Vassallo, Camilla
AU - Brazzelli, Valeria
AU - Martinoli, Sara
AU - Ardigò, Marco
AU - Alessandrino, Paolo Emilio
AU - Borroni, Riccardo Giovanni
AU - Franchini, Pietro
PY - 2004/6
Y1 - 2004/6
N2 - Radiation recall dermatitis is one of the skin sequelae that may affect oncology patients. It occurs in a previously irradiated field, when subsequent chemotherapy is given. The eruption may be elicited by chemotherapy, even several months after radiotherapy. Its mechanism is poorly understood, and the histopathologic findings have received, to date, only sketchy descriptions. A 55-year-old male affected by multiple myeloma received radiation therapy both on his left coxofemoral area, and lumbar region (D11-L1). After cyclophosphamide administration, he developed 2 well defined square-shaped, infiltrated erythematoviolaceous plaques in the prior irradiated fields. Histopathologic findings revealed a diffusely fibrosclerosing process, involving deep dermis, hypodermis, as well as the underlying muscle, while sparing the epidermis and superficial-mid dermis. Histopathology was indistinguishable from deep radio-dermatitis, panniculitis, and myositis. This is the first case providing clear evidence of the causative role of cyclophosphamide in inducing a cutaneous and subcutaneous radiation recall reaction.
AB - Radiation recall dermatitis is one of the skin sequelae that may affect oncology patients. It occurs in a previously irradiated field, when subsequent chemotherapy is given. The eruption may be elicited by chemotherapy, even several months after radiotherapy. Its mechanism is poorly understood, and the histopathologic findings have received, to date, only sketchy descriptions. A 55-year-old male affected by multiple myeloma received radiation therapy both on his left coxofemoral area, and lumbar region (D11-L1). After cyclophosphamide administration, he developed 2 well defined square-shaped, infiltrated erythematoviolaceous plaques in the prior irradiated fields. Histopathologic findings revealed a diffusely fibrosclerosing process, involving deep dermis, hypodermis, as well as the underlying muscle, while sparing the epidermis and superficial-mid dermis. Histopathology was indistinguishable from deep radio-dermatitis, panniculitis, and myositis. This is the first case providing clear evidence of the causative role of cyclophosphamide in inducing a cutaneous and subcutaneous radiation recall reaction.
KW - Cyclophosphamide
KW - Histopathologic findings
KW - Myositis
KW - Panniculitis
KW - Radiation recall dermatitis
UR - http://www.scopus.com/inward/record.url?scp=2442640100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2442640100&partnerID=8YFLogxK
U2 - 10.1097/00000372-200406000-00008
DO - 10.1097/00000372-200406000-00008
M3 - Article
C2 - 15166509
AN - SCOPUS:2442640100
VL - 26
SP - 213
EP - 216
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
SN - 0193-1091
IS - 3
ER -