Terapia radiante dopo ricostruzione mammaria: esiti, complicazioni e soddisfazione delle pazienti

Translated title of the contribution: Radiation therapy after breast reconstruction: Outcomes, complications, and patient satisfaction

Alessia Carnevale, Claudia Scaringi, Giovanna Scalabrino, Barbara Campanella, Mattia Falchetto Osti, Vitaliana De Sanctis, Maurizio Valeriani, Giuseppe Minniti, Claudio Amanti, Fabio Santanelli, Riccardo Maurizi Enrici

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: The aim of this study was to evaluate treatmentrelated complications, outcomes, and patient satisfaction in women with locally advanced breast cancer who received post-mastectomy radiation therapy (PMRT) after breast reconstruction (BR). Materials and methods: Between October 2007 and November 2010, 46 patients with locally advanced breast cancer who underwent mastectomy followed by BR received PMRT at our Department. Radiotherapy was delivered to the chest wall with a dose of 50 Gy in 25 fractions over 5 weeks. Results: The median follow-up was 19 months. Skin erythema grade 1 and 2 was seen in 44 (96%) and two (4%) patients, respectively. Major complications, requiring additional corrective surgical procedure, occurred in three (7%) patients (one patient with prosthesis, one patient with tissue expander and one patient with deep inferior epigastric perforator flap). At univariate analysis, smoking, chemotherapy, hormone therapy with tamoxifen and reconstruction with implant were associated with overall complications (capsular contracture and reconstruction failure). Forty (86%) patients were very satisfied or satisfied with the cosmetic outcome of reconstruction. Conclusions: Radiotherapy can be safely delivered after BR, with a low complication rate and good patient satisfaction. Further randomised studies are needed to better define the optimal timing of breast reconstruction and post-mastectomy radiation therapy.

Translated title of the contributionRadiation therapy after breast reconstruction: Outcomes, complications, and patient satisfaction
Original languageItalian
Pages (from-to)1240-1250
Number of pages11
JournalRadiologia Medica
Volume118
Issue number7
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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