Radical dissection after positive groin sentinel biopsy in melanoma patients: Rate of further positive nodes

Mario Santinami, Antonino Carbone, Federica Crippa, Andrea Maurichi, Cristina Pellitteri, Roberta Ruggeri, Odysseas Zoras, Roberto Patuzzo

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this retrospective study was to analyze the incidence of further nonsentinel node metastases at completion lymphadenectomy of the groin after a positive sentinel node biopsy to evaluate whether radical dissection remains the treatment of choice for these patients. Patients treated at the National Cancer Institute of Milan between January 1999 and December 2006 were reviewed retrospectively. The analysis included patients with a diagnosis of positive sentinel node biopsy of the groin (clinically negative) who underwent completion groin, iliac, and obturatory dissections. The primary melanoma was located on the lower extremities and trunk in 82.5 and 17.5%, respectively. The median follow-up was more than 30 months. The number of positive sentinel nodes was considered, as well as the size and location of the metastases (micro vs. macro). After radical dissection, the number and the location (groin, iliac, or groin+iliac nodes) of further nonsentinel node metastases were analyzed. The frequency of further nonsentinel node metastases at completion of groin dissection was correlated to Breslow's thickness and to the characteristics of t'mm, or Clark's IV-V) underwent lymphatic mapping and sentinel node biopsy: 752 patients had sentinel node biopsy at the groin basin; among these, 150 (20%) patients presented positive sentinel node biopsy and underwent completion radical dissection (groin, obturatory, and external iliac+obturatory radical node dissections). We found further positive nonsentinel node metastases in 36 of 150 (24%) patients, 69% (25 of 36) of which were located in the iliac-obturator area and 31% in the groin area only: 16 patients (44.4%) had one additional metastatic node and seven patients (19.4%) had two, whereas 13 (36.1%) had three or more. In 22 cases (61.1%), the sentinel node showed a macrometastasis (>2'mm deposit in the node) and in 14 cases (38.9%) a micrometastasis (

Original languageEnglish
Pages (from-to)112-118
Number of pages7
JournalMelanoma Research
Volume19
Issue number2
DOIs
Publication statusPublished - Apr 2009

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Dermatology

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