Radical en bloc resection for lung cancer invading the spine

Dominique H. Grunenwald, Christian Mazel, Philippe Girard, Giulia Veronesi, Lorenzo Spaggiari, Dominique Gossot, Denis Debrosse, Raffaele Caliandro, Jean Luc Le Guillou, Thierry Le Chevalier

Research output: Contribution to journalArticle

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Abstract

Objective: We reviewed our 8-year experience with en bloc partial and total vertebrectomy for lung cancer invading the spine and report outcome and survival. Methods: Nineteen patients with lung cancers involving the spine underwent en bloc resection. Eleven received induction treatment (chemotherapy, n = 5; chemoradiotherapy, n = 4; and radiation, n = 2). Pneumonectomy was performed in 3 patients, lobectomy in 13 patients, and wedge resection in 3 patients. Hemivertebrectomy was performed in 15 patients, and total vertebrectomy was performed in 4 patients. The median number of resected vertebral bodies was 3 (range, 1-4). Tumor stage was IIIB in 14 patients, IIIA in 1 patient, and IIB in 4 patients (hemivertebrectomy is performed in the case of T3 disease to obtain free margins). Surgical nodal status was NO in 13 patients, N1 in 3 patients, N2 in 1 patient, and N3 (supraclavicular) in 2 patients. Complete macroscopic and microscopic resection was achieved in 15 (79%) patients. Results: There was no immediate postoperative mortality. Morbidity was observed in 10 patients, including 4 (21%) complications related to the spinal surgery. The median hospital stay was 30 days. Seven patients were alive after a mean follow-up of 26 months (range, 7-74 months). The 1- and 5-year predicted survivals (updated) are 59% and 14%, respectively. Nine local recurrences were observed. Conclusions: En bloc resection of chest tumors with vertebrectomy is technically demanding, and postoperative morbidity should be critically addressed with this aggressive surgical intervention. However, an encouraging long-term survival observed in this series suggests that en bloc resection could be a valid option in selected patients with vertebral involvement of chest tumors.

Original languageEnglish
Pages (from-to)271-279
Number of pages9
JournalJournal of Thoracic and Cardiovascular Surgery
Volume123
Issue number2
DOIs
Publication statusPublished - 2002

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Lung Neoplasms
Spine
Survival
Thorax
Morbidity
Neoplasms
Induction Chemotherapy
Pneumonectomy
Chemoradiotherapy
Length of Stay

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Radical en bloc resection for lung cancer invading the spine. / Grunenwald, Dominique H.; Mazel, Christian; Girard, Philippe; Veronesi, Giulia; Spaggiari, Lorenzo; Gossot, Dominique; Debrosse, Denis; Caliandro, Raffaele; Le Guillou, Jean Luc; Le Chevalier, Thierry.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 123, No. 2, 2002, p. 271-279.

Research output: Contribution to journalArticle

Grunenwald, DH, Mazel, C, Girard, P, Veronesi, G, Spaggiari, L, Gossot, D, Debrosse, D, Caliandro, R, Le Guillou, JL & Le Chevalier, T 2002, 'Radical en bloc resection for lung cancer invading the spine', Journal of Thoracic and Cardiovascular Surgery, vol. 123, no. 2, pp. 271-279. https://doi.org/10.1067/mtc.2002.119333
Grunenwald, Dominique H. ; Mazel, Christian ; Girard, Philippe ; Veronesi, Giulia ; Spaggiari, Lorenzo ; Gossot, Dominique ; Debrosse, Denis ; Caliandro, Raffaele ; Le Guillou, Jean Luc ; Le Chevalier, Thierry. / Radical en bloc resection for lung cancer invading the spine. In: Journal of Thoracic and Cardiovascular Surgery. 2002 ; Vol. 123, No. 2. pp. 271-279.
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AU - Mazel, Christian

AU - Girard, Philippe

AU - Veronesi, Giulia

AU - Spaggiari, Lorenzo

AU - Gossot, Dominique

AU - Debrosse, Denis

AU - Caliandro, Raffaele

AU - Le Guillou, Jean Luc

AU - Le Chevalier, Thierry

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N2 - Objective: We reviewed our 8-year experience with en bloc partial and total vertebrectomy for lung cancer invading the spine and report outcome and survival. Methods: Nineteen patients with lung cancers involving the spine underwent en bloc resection. Eleven received induction treatment (chemotherapy, n = 5; chemoradiotherapy, n = 4; and radiation, n = 2). Pneumonectomy was performed in 3 patients, lobectomy in 13 patients, and wedge resection in 3 patients. Hemivertebrectomy was performed in 15 patients, and total vertebrectomy was performed in 4 patients. The median number of resected vertebral bodies was 3 (range, 1-4). Tumor stage was IIIB in 14 patients, IIIA in 1 patient, and IIB in 4 patients (hemivertebrectomy is performed in the case of T3 disease to obtain free margins). Surgical nodal status was NO in 13 patients, N1 in 3 patients, N2 in 1 patient, and N3 (supraclavicular) in 2 patients. Complete macroscopic and microscopic resection was achieved in 15 (79%) patients. Results: There was no immediate postoperative mortality. Morbidity was observed in 10 patients, including 4 (21%) complications related to the spinal surgery. The median hospital stay was 30 days. Seven patients were alive after a mean follow-up of 26 months (range, 7-74 months). The 1- and 5-year predicted survivals (updated) are 59% and 14%, respectively. Nine local recurrences were observed. Conclusions: En bloc resection of chest tumors with vertebrectomy is technically demanding, and postoperative morbidity should be critically addressed with this aggressive surgical intervention. However, an encouraging long-term survival observed in this series suggests that en bloc resection could be a valid option in selected patients with vertebral involvement of chest tumors.

AB - Objective: We reviewed our 8-year experience with en bloc partial and total vertebrectomy for lung cancer invading the spine and report outcome and survival. Methods: Nineteen patients with lung cancers involving the spine underwent en bloc resection. Eleven received induction treatment (chemotherapy, n = 5; chemoradiotherapy, n = 4; and radiation, n = 2). Pneumonectomy was performed in 3 patients, lobectomy in 13 patients, and wedge resection in 3 patients. Hemivertebrectomy was performed in 15 patients, and total vertebrectomy was performed in 4 patients. The median number of resected vertebral bodies was 3 (range, 1-4). Tumor stage was IIIB in 14 patients, IIIA in 1 patient, and IIB in 4 patients (hemivertebrectomy is performed in the case of T3 disease to obtain free margins). Surgical nodal status was NO in 13 patients, N1 in 3 patients, N2 in 1 patient, and N3 (supraclavicular) in 2 patients. Complete macroscopic and microscopic resection was achieved in 15 (79%) patients. Results: There was no immediate postoperative mortality. Morbidity was observed in 10 patients, including 4 (21%) complications related to the spinal surgery. The median hospital stay was 30 days. Seven patients were alive after a mean follow-up of 26 months (range, 7-74 months). The 1- and 5-year predicted survivals (updated) are 59% and 14%, respectively. Nine local recurrences were observed. Conclusions: En bloc resection of chest tumors with vertebrectomy is technically demanding, and postoperative morbidity should be critically addressed with this aggressive surgical intervention. However, an encouraging long-term survival observed in this series suggests that en bloc resection could be a valid option in selected patients with vertebral involvement of chest tumors.

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