Radical oncologic surgery affects the circulatory levels of interleukin 10

Luca Gianotti, Claudio Fortis, Marco Braca, Oreste Gentilini, Andrea Vignali, Valerio Di Carlo

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objective: Interleukin 10 (IL-10) has been shown to be elevated in the plasma of cancer-bearing patients. The source of systemic IL- 10 may be the tumor microenvironment. We therefore tried to evaluate if ablative surgery for gastrointestinal cancer could affect the levels of circulating IL-10. Methods: Plasma IL-10 concentration was measured in 45 patients with adenocarcinoma of the gastrointestinal tract. Forty healthy subjects, 15 women undergoing hysterectomy for uterine fibroma, and 15 patients undergoing palliative operation for pancreatic cancer were used as control groups. Plasma IL-10 was assessed I day before surgery (baseline) and 1, 4, and 8 days after operation. Results: The baseline concentration of IL- 10 was significantly higher in cancer patients than in healthy subjects and in women with fibroma (8.6 ng/mL, 2.1 and 1.8 respectively; P = 0.015). After radical surgery, the IL-10 levels significantly dropped in cancer patients (from 8.6 ng/mL to 3.8; P = 0.024), whereas in subjects undergoing palliative operation, the concentration remained elevated (8.5 ng/mL baseline versus 7.9 on day +1). Conclusions: The origin of circulating IL-10 may be the tumor microenvironment.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalJournal of Surgical Oncology
Volume66
Issue number4
DOIs
Publication statusPublished - Dec 1997

Keywords

  • Adenocarcinoma
  • Interleukin 10
  • Neoplasm
  • Oncologic surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Radical oncologic surgery affects the circulatory levels of interleukin 10'. Together they form a unique fingerprint.

Cite this