Radical resection of radiation-induced sarcoma of the chest wall

Report of 15 cases

Alain R. Chapelier, Emile A. Bacha, Vincent Thomas De Montpreville, Elisabeth M. Dulmet, Mario Rietjens, Alvaro Margulis, Paolo Macchiarini, Philippe G. Dartevelle

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Abstract

Background. Surgical management of radiation-induced sarcoma of the chest wall remains difficult because of its impressive local aggressiveness. Methods. Between 1987 and 1995, 15 patients (median age, 58 years) underwent radical resection of radiation-induced sarcoma of the chest wall. This type of tumor was defined as a metachronous, histologically different neoplasm in the irradiated field of the original tumor. Ten patients had a history of primary breast cancer and 5 patients, Hodgkin's disease. The median delivered radiation dose to the primary tumor area was 45 Gy, and the median interval between radiotherapy and diagnosis of sarcoma was 14 years. Seven tumors were located on the sternum, three on the lateral chest wall, and five in the thoracic outlet. Four total and three partial sternectomies, three lateral chest wall resections and five resections of tumors in the thoracic outlet (three first-rib resections) were performed. Seven patients required stabilization of the chest wall with prosthetic material. Soft tissue reconstruction was carried out with either muscle flaps and skin advancement in 9, musculocutaneous flaps in 4, or skin flaps alone in 2 patients. Results. One patient died 3 months after total sternectomy of respiratory failure. Two patients (13.3%) had a local complication: sepsis after sternectomy in 1 and cutaneous necrosis in 1. Local recurrence occurred in 7 patients after a median interval of 10 months. Two of them died, and 4 underwent a repeat resection, 3 of whom are still alive. Four patients died of systemic recurrence. With a median follow-up of 30 months, overall 5-year survival and 5-year disease-free survival rates were 48% and 27%, respectively. Conclusion. Despite poor long-term disease-free survival, radical resection of radiation-induced sarcoma of the chest wall is justified on the basis of low postoperative morbidity and the lack of other available therapies.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalAnnals of Thoracic Surgery
Volume63
Issue number1
DOIs
Publication statusPublished - Jan 1997

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Thoracic Wall
Sarcoma
Radiation
Neoplasms
Skin
Disease-Free Survival
Thorax
Recurrence
Sternum
Myocutaneous Flap
Ribs
Hodgkin Disease
Respiratory Insufficiency
Free Radicals
Sepsis
Necrosis
Radiotherapy
Survival Rate
Breast Neoplasms
Morbidity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Chapelier, A. R., Bacha, E. A., De Montpreville, V. T., Dulmet, E. M., Rietjens, M., Margulis, A., ... Dartevelle, P. G. (1997). Radical resection of radiation-induced sarcoma of the chest wall: Report of 15 cases. Annals of Thoracic Surgery, 63(1), 214-219. https://doi.org/10.1016/S0003-4975(96)00927-7

Radical resection of radiation-induced sarcoma of the chest wall : Report of 15 cases. / Chapelier, Alain R.; Bacha, Emile A.; De Montpreville, Vincent Thomas; Dulmet, Elisabeth M.; Rietjens, Mario; Margulis, Alvaro; Macchiarini, Paolo; Dartevelle, Philippe G.

In: Annals of Thoracic Surgery, Vol. 63, No. 1, 01.1997, p. 214-219.

Research output: Contribution to journalArticle

Chapelier, AR, Bacha, EA, De Montpreville, VT, Dulmet, EM, Rietjens, M, Margulis, A, Macchiarini, P & Dartevelle, PG 1997, 'Radical resection of radiation-induced sarcoma of the chest wall: Report of 15 cases', Annals of Thoracic Surgery, vol. 63, no. 1, pp. 214-219. https://doi.org/10.1016/S0003-4975(96)00927-7
Chapelier, Alain R. ; Bacha, Emile A. ; De Montpreville, Vincent Thomas ; Dulmet, Elisabeth M. ; Rietjens, Mario ; Margulis, Alvaro ; Macchiarini, Paolo ; Dartevelle, Philippe G. / Radical resection of radiation-induced sarcoma of the chest wall : Report of 15 cases. In: Annals of Thoracic Surgery. 1997 ; Vol. 63, No. 1. pp. 214-219.
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abstract = "Background. Surgical management of radiation-induced sarcoma of the chest wall remains difficult because of its impressive local aggressiveness. Methods. Between 1987 and 1995, 15 patients (median age, 58 years) underwent radical resection of radiation-induced sarcoma of the chest wall. This type of tumor was defined as a metachronous, histologically different neoplasm in the irradiated field of the original tumor. Ten patients had a history of primary breast cancer and 5 patients, Hodgkin's disease. The median delivered radiation dose to the primary tumor area was 45 Gy, and the median interval between radiotherapy and diagnosis of sarcoma was 14 years. Seven tumors were located on the sternum, three on the lateral chest wall, and five in the thoracic outlet. Four total and three partial sternectomies, three lateral chest wall resections and five resections of tumors in the thoracic outlet (three first-rib resections) were performed. Seven patients required stabilization of the chest wall with prosthetic material. Soft tissue reconstruction was carried out with either muscle flaps and skin advancement in 9, musculocutaneous flaps in 4, or skin flaps alone in 2 patients. Results. One patient died 3 months after total sternectomy of respiratory failure. Two patients (13.3{\%}) had a local complication: sepsis after sternectomy in 1 and cutaneous necrosis in 1. Local recurrence occurred in 7 patients after a median interval of 10 months. Two of them died, and 4 underwent a repeat resection, 3 of whom are still alive. Four patients died of systemic recurrence. With a median follow-up of 30 months, overall 5-year survival and 5-year disease-free survival rates were 48{\%} and 27{\%}, respectively. Conclusion. Despite poor long-term disease-free survival, radical resection of radiation-induced sarcoma of the chest wall is justified on the basis of low postoperative morbidity and the lack of other available therapies.",
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AU - Chapelier, Alain R.

AU - Bacha, Emile A.

AU - De Montpreville, Vincent Thomas

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AU - Rietjens, Mario

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N2 - Background. Surgical management of radiation-induced sarcoma of the chest wall remains difficult because of its impressive local aggressiveness. Methods. Between 1987 and 1995, 15 patients (median age, 58 years) underwent radical resection of radiation-induced sarcoma of the chest wall. This type of tumor was defined as a metachronous, histologically different neoplasm in the irradiated field of the original tumor. Ten patients had a history of primary breast cancer and 5 patients, Hodgkin's disease. The median delivered radiation dose to the primary tumor area was 45 Gy, and the median interval between radiotherapy and diagnosis of sarcoma was 14 years. Seven tumors were located on the sternum, three on the lateral chest wall, and five in the thoracic outlet. Four total and three partial sternectomies, three lateral chest wall resections and five resections of tumors in the thoracic outlet (three first-rib resections) were performed. Seven patients required stabilization of the chest wall with prosthetic material. Soft tissue reconstruction was carried out with either muscle flaps and skin advancement in 9, musculocutaneous flaps in 4, or skin flaps alone in 2 patients. Results. One patient died 3 months after total sternectomy of respiratory failure. Two patients (13.3%) had a local complication: sepsis after sternectomy in 1 and cutaneous necrosis in 1. Local recurrence occurred in 7 patients after a median interval of 10 months. Two of them died, and 4 underwent a repeat resection, 3 of whom are still alive. Four patients died of systemic recurrence. With a median follow-up of 30 months, overall 5-year survival and 5-year disease-free survival rates were 48% and 27%, respectively. Conclusion. Despite poor long-term disease-free survival, radical resection of radiation-induced sarcoma of the chest wall is justified on the basis of low postoperative morbidity and the lack of other available therapies.

AB - Background. Surgical management of radiation-induced sarcoma of the chest wall remains difficult because of its impressive local aggressiveness. Methods. Between 1987 and 1995, 15 patients (median age, 58 years) underwent radical resection of radiation-induced sarcoma of the chest wall. This type of tumor was defined as a metachronous, histologically different neoplasm in the irradiated field of the original tumor. Ten patients had a history of primary breast cancer and 5 patients, Hodgkin's disease. The median delivered radiation dose to the primary tumor area was 45 Gy, and the median interval between radiotherapy and diagnosis of sarcoma was 14 years. Seven tumors were located on the sternum, three on the lateral chest wall, and five in the thoracic outlet. Four total and three partial sternectomies, three lateral chest wall resections and five resections of tumors in the thoracic outlet (three first-rib resections) were performed. Seven patients required stabilization of the chest wall with prosthetic material. Soft tissue reconstruction was carried out with either muscle flaps and skin advancement in 9, musculocutaneous flaps in 4, or skin flaps alone in 2 patients. Results. One patient died 3 months after total sternectomy of respiratory failure. Two patients (13.3%) had a local complication: sepsis after sternectomy in 1 and cutaneous necrosis in 1. Local recurrence occurred in 7 patients after a median interval of 10 months. Two of them died, and 4 underwent a repeat resection, 3 of whom are still alive. Four patients died of systemic recurrence. With a median follow-up of 30 months, overall 5-year survival and 5-year disease-free survival rates were 48% and 27%, respectively. Conclusion. Despite poor long-term disease-free survival, radical resection of radiation-induced sarcoma of the chest wall is justified on the basis of low postoperative morbidity and the lack of other available therapies.

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