Radically resected pituitary adenomas: Prognostic role of Ki 67 labeling index in a monocentric retrospective series and literature review

Sabrina Chiloiro, Antonio Bianchi, Francesco Doglietto, Chiara De Waure, Antonella Giampietro, Alessandra Fusco, Donato Iacovazzo, Linda Tartaglione, Francesco Di Nardo, Francesco Signorelli, Libero Lauriola, Carmelo Anile, Guido Rindi, Giulio Maira, Alfredo Pontecorvi, Laura De Marinis

Research output: Contribution to journalArticle

Abstract

Ki-67 Labeling Index is an immunocytochemical marker of cell proliferation. The correlation of Ki-67 expression with pituitary adenomas recurrence has been investigated and is highly debated. Aim of this study was to evaluate whether Ki-67 correlates with recurrence even in patients with an apparently completely removed pituitary adenoma. We retrospectively reviewed the database of the Hypothalamic-Pituitary Disease Unit at the Catholic University of Rome, collected between 2003 and 2011. Inclusion criteria were: patients who underwent surgery at the Department of Neurosurgery with an apparently complete removal of a pituitary adenoma; Ki-67 histological evaluation by the same operator and values of

Original languageEnglish
Pages (from-to)267-276
Number of pages10
JournalPituitary
Volume17
Issue number3
DOIs
Publication statusPublished - 2014

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Keywords

  • Complete removal
  • Disease-free survival
  • Ki-67
  • Pituitary adenoma
  • Recurrence

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Chiloiro, S., Bianchi, A., Doglietto, F., De Waure, C., Giampietro, A., Fusco, A., Iacovazzo, D., Tartaglione, L., Di Nardo, F., Signorelli, F., Lauriola, L., Anile, C., Rindi, G., Maira, G., Pontecorvi, A., & De Marinis, L. (2014). Radically resected pituitary adenomas: Prognostic role of Ki 67 labeling index in a monocentric retrospective series and literature review. Pituitary, 17(3), 267-276. https://doi.org/10.1007/s11102-013-0500-6