Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

MA Panaro, A Aloisi, G Nicolardi, DD Lofrumento, F de Nuccio, V la Pesa, A Cianciulli, R Rinaldi, R Calvello, V Fontani, S Rinaldi

Research output: Contribution to journalArticle

Abstract

In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism. © 2017 Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd.
Original languageEnglish
Pages (from-to)270-282
Number of pages13
JournalNeuroscience Bulletin
Volume34
Issue number2
DOIs
Publication statusPublished - 2018

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Radio
Technology
Parkinsonian Disorders
Corpus Striatum
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Biological Science Disciplines
Singapore
Astrocytes
Anti-Inflammatory Agents
4-phenyl-1,2,3,6-tetrahydropyridine

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Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration. / Panaro, MA; Aloisi, A; Nicolardi, G; Lofrumento, DD; de Nuccio, F; la Pesa, V; Cianciulli, A; Rinaldi, R; Calvello, R; Fontani, V; Rinaldi, S.

In: Neuroscience Bulletin, Vol. 34, No. 2, 2018, p. 270-282.

Research output: Contribution to journalArticle

Panaro, MA, Aloisi, A, Nicolardi, G, Lofrumento, DD, de Nuccio, F, la Pesa, V, Cianciulli, A, Rinaldi, R, Calvello, R, Fontani, V & Rinaldi, S 2018, 'Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration', Neuroscience Bulletin, vol. 34, no. 2, pp. 270-282. https://doi.org/10.1007/s12264-017-0188-0
Panaro, MA ; Aloisi, A ; Nicolardi, G ; Lofrumento, DD ; de Nuccio, F ; la Pesa, V ; Cianciulli, A ; Rinaldi, R ; Calvello, R ; Fontani, V ; Rinaldi, S. / Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration. In: Neuroscience Bulletin. 2018 ; Vol. 34, No. 2. pp. 270-282.
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AU - de Nuccio, F

AU - la Pesa, V

AU - Cianciulli, A

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