Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 270-282 |
| Number of pages | 13 |
| Journal | Neuroscience Bulletin |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2018 |
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Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration. / Panaro, MA; Aloisi, A; Nicolardi, G; Lofrumento, DD; de Nuccio, F; la Pesa, V; Cianciulli, A; Rinaldi, R; Calvello, R; Fontani, V; Rinaldi, S.
In: Neuroscience Bulletin, Vol. 34, No. 2, 2018, p. 270-282.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration
AU - Panaro, MA
AU - Aloisi, A
AU - Nicolardi, G
AU - Lofrumento, DD
AU - de Nuccio, F
AU - la Pesa, V
AU - Cianciulli, A
AU - Rinaldi, R
AU - Calvello, R
AU - Fontani, V
AU - Rinaldi, S
PY - 2018
Y1 - 2018
N2 - In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism. © 2017 Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd.
AB - In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism. © 2017 Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd.
U2 - 10.1007/s12264-017-0188-0
DO - 10.1007/s12264-017-0188-0
M3 - Article
VL - 34
SP - 270
EP - 282
JO - Neuroscience Bulletin
JF - Neuroscience Bulletin
SN - 1673-7067
IS - 2
ER -