Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

MA Panaro, A Aloisi, G Nicolardi, DD Lofrumento, F de Nuccio, V la Pesa, A Cianciulli, R Rinaldi, R Calvello, V Fontani, S Rinaldi

Research output: Contribution to journalArticlepeer-review

Abstract

In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism. © 2017 Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd.
Original languageEnglish
Pages (from-to)270-282
Number of pages13
JournalNeuroscience Bulletin
Volume34
Issue number2
DOIs
Publication statusPublished - 2018

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