Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

MA Panaro; A Aloisi; G Nicolardi; DD Lofrumento; F de Nuccio; V la Pesa; A Cianciulli; R Rinaldi; R Calvello; V Fontani; S Rinaldi

doi:10.1007/s12264-017-0188-0

Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration

MA Panaro, A Aloisi, G Nicolardi, DD Lofrumento, F de Nuccio, V la Pesa, A Cianciulli, R Rinaldi, R Calvello, V Fontani, S Rinaldi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism. © 2017 Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd.

Original language	English
Pages (from-to)	270-282
Number of pages	13
Journal	Neuroscience Bulletin
Volume	34
Issue number	2
DOIs	https://doi.org/10.1007/s12264-017-0188-0
Publication status	Published - 2018

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Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration. / Panaro, MA; Aloisi, A; Nicolardi, G; Lofrumento, DD; de Nuccio, F; la Pesa, V; Cianciulli, A; Rinaldi, R; Calvello, R; Fontani, V; Rinaldi, S.

In: Neuroscience Bulletin, Vol. 34, No. 2, 2018, p. 270-282.

Research output: Contribution to journal › Article › peer-review

@article{d9fe5a886f6548edb1997151f55e102b,

title = "Radio Electric Asymmetric Conveyer Technology Modulates Neuroinflammation in a Mouse Model of Neurodegeneration",

abstract = "In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism. {\textcopyright} 2017 Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd.",

author = "MA Panaro and A Aloisi and G Nicolardi and DD Lofrumento and {de Nuccio}, F and {la Pesa}, V and A Cianciulli and R Rinaldi and R Calvello and V Fontani and S Rinaldi",

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AU - Panaro, MA

AU - Aloisi, A

AU - Nicolardi, G

AU - Lofrumento, DD

AU - de Nuccio, F

AU - la Pesa, V

AU - Cianciulli, A

AU - Rinaldi, R

AU - Calvello, R

AU - Fontani, V

AU - Rinaldi, S

PY - 2018

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AB - In this study, the effects of Radio Electric Asymmetric Conveyer (REAC), a non-invasive physical treatment, on neuroinflammatory responses in a mouse model of parkinsonism induced by intoxication with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), were investigated in vivo. We found that the REAC tissue optimization treatment specific for neuro-regenerative purposes (REAC TO-RGN-N) attenuated the inflammatory picture evoked by MPTP-induced nigro-striatal damage in mice, decreasing the levels of pro-inflammatory molecules and increasing anti-inflammatory mediators. Besides, there was a significant reduction of both astrocyte and microglial activation in MPTP-treated mice exposed to REAC TO-RGN-N. These results indicated that REAC TO-RGN-N treatment modulates the pro-inflammatory responses and reduces neuronal damage in MPTP-induced parkinsonism. © 2017 Shanghai Institutes for Biological Sciences, CAS and Springer Nature Singapore Pte Ltd.

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