Radio-frequency dielectric spectroscopy of synthetic bilayers containing glycolipids

C. Cametti, F. De Luca, M. A. Macrib, B. Maraviglia, R. Misasi, M. Sorice

Research output: Contribution to journalArticle

Abstract

The electrical conductivity of aqueous solutions of colloidal phospholipid-ganglioside mixtures has been measured in the frequency range from 10 kHz to 100 MHz, where a conductivity dispersion due to the interfacial polarization occurs. Insertion of GM1 ganglioside in the phospholipid bilayer alters markedly the electrical behaviour of the whole suspension that exhibits some interesting features, which depend on the GM1 concentration. In a restricted range of the ganglioside concentration, the experimental data can be partially explained by introducing a surface conductivity contribution in the usual conductivity theory of heterogeneous systems. Although preliminary, these measurements indicate that gangliosides, according to the structural shape they assume, modify the electrical properties of the lipid bilayer. This effect may be relevant to understanding ganglioside interactions with lipid components of biological cell membranes.

Original languageEnglish
Pages (from-to)173-176
Number of pages4
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume72
Issue numberC
DOIs
Publication statusPublished - Jun 17 1993

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Keywords

  • Glycolipids
  • radio-frequency dielectric spectroscopy
  • synthetic bilayers.

ASJC Scopus subject areas

  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry

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