Radio-guided surgery with β radiation

Tests on ex-vivo specimens

C. Mancini-Terracciano, V. Bocci, M. Colandrea, F. Collamati, M. Cremonesi, R. Faccini, M. E. Ferrari, P. Ferroli, F. Ghielmetti, C. M. Grana, M. Marafini, S. Morganti, S. Papi, M. Patané, G. Pedroli, B. Pollo, A. Russomando, M. Schiariti, G. Traini, E. Solfaroli Camillocci

Research output: Contribution to journalConference article

Abstract

Radio-Guided Surgery (RGS) is a surgical technique aimed at assisting the surgeon to reach as complete a resection of the tumoural lesion as possible. Established methods to date make use of γ -emitting tracers to radio-mark the neoplastic tissue. However, in case of uptake from healthy organs around the lesion the large penetration of photons yields a non-negligible background that can limit the RGS application. The adoption of β radiation has been proposed to overcome this limit. To validate the entire RGS procedure, from the evaluation of the tracer uptake of the tumor, to the assumptions on the bio-distribution and the signal detection, tests on ex vivo specimens of meningioma brain tumour were performed. Meningioma was selected due to the well known high receptivity to a β emitting radio-tracer already in use in the clinical practice: 90Y-labelled DOTATOC. Patients were enrolled according to the tumour Standard Uptake Value (SUV > 2) and the expected Tumour to Non-tumour Ratio (TNR > 10) estimated from 68Ga-DOTATOC PET images. After injecting the patients with 93–167, MBq of 90Y - DOTATOC, 26 samples excised during surgery were examined with a dedicated β detecting probe to assess the sensitivity of millimetre-sized tumour remnants in case of administration of low activity value compatible with those injected for diagnostic exams. Even injecting as low as 1.4, MBq/kg of radio-tracer, tumour remnants greater than 0.06, ml would be discriminated by the healthy tissue in few seconds.

Original languageEnglish
Pages (from-to)693-697
Number of pages5
JournalIFMBE Proceedings
Volume68
Issue number3
DOIs
Publication statusPublished - Jan 1 2019
EventWorld Congress on Medical Physics and Biomedical Engineering, WC 2018 - Prague, Czech Republic
Duration: Jun 3 2018Jun 8 2018

Fingerprint

Surgery
Tumors
Radiation
Tissue
Signal detection
Brain
Photons

Keywords

  • Intraoperative imaging
  • Meningioma brain tumor
  • Radioguided surgery
  • β radiation

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering

Cite this

Mancini-Terracciano, C., Bocci, V., Colandrea, M., Collamati, F., Cremonesi, M., Faccini, R., ... Solfaroli Camillocci, E. (2019). Radio-guided surgery with β radiation: Tests on ex-vivo specimens. IFMBE Proceedings, 68(3), 693-697. https://doi.org/10.1007/978-981-10-9023-3_126

Radio-guided surgery with β radiation : Tests on ex-vivo specimens. / Mancini-Terracciano, C.; Bocci, V.; Colandrea, M.; Collamati, F.; Cremonesi, M.; Faccini, R.; Ferrari, M. E.; Ferroli, P.; Ghielmetti, F.; Grana, C. M.; Marafini, M.; Morganti, S.; Papi, S.; Patané, M.; Pedroli, G.; Pollo, B.; Russomando, A.; Schiariti, M.; Traini, G.; Solfaroli Camillocci, E.

In: IFMBE Proceedings, Vol. 68, No. 3, 01.01.2019, p. 693-697.

Research output: Contribution to journalConference article

Mancini-Terracciano, C, Bocci, V, Colandrea, M, Collamati, F, Cremonesi, M, Faccini, R, Ferrari, ME, Ferroli, P, Ghielmetti, F, Grana, CM, Marafini, M, Morganti, S, Papi, S, Patané, M, Pedroli, G, Pollo, B, Russomando, A, Schiariti, M, Traini, G & Solfaroli Camillocci, E 2019, 'Radio-guided surgery with β radiation: Tests on ex-vivo specimens', IFMBE Proceedings, vol. 68, no. 3, pp. 693-697. https://doi.org/10.1007/978-981-10-9023-3_126
Mancini-Terracciano, C. ; Bocci, V. ; Colandrea, M. ; Collamati, F. ; Cremonesi, M. ; Faccini, R. ; Ferrari, M. E. ; Ferroli, P. ; Ghielmetti, F. ; Grana, C. M. ; Marafini, M. ; Morganti, S. ; Papi, S. ; Patané, M. ; Pedroli, G. ; Pollo, B. ; Russomando, A. ; Schiariti, M. ; Traini, G. ; Solfaroli Camillocci, E. / Radio-guided surgery with β radiation : Tests on ex-vivo specimens. In: IFMBE Proceedings. 2019 ; Vol. 68, No. 3. pp. 693-697.
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