TY - JOUR
T1 - Radio-guided surgery with β− radiation
T2 - World Congress on Medical Physics and Biomedical Engineering, WC 2018
AU - Mancini-Terracciano, C.
AU - Bocci, V.
AU - Colandrea, M.
AU - Collamati, F.
AU - Cremonesi, M.
AU - Faccini, R.
AU - Ferrari, M. E.
AU - Ferroli, P.
AU - Ghielmetti, F.
AU - Grana, C. M.
AU - Marafini, M.
AU - Morganti, S.
AU - Papi, S.
AU - Patané, M.
AU - Pedroli, G.
AU - Pollo, B.
AU - Russomando, A.
AU - Schiariti, M.
AU - Traini, G.
AU - Solfaroli Camillocci, E.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Radio-Guided Surgery (RGS) is a surgical technique aimed at assisting the surgeon to reach as complete a resection of the tumoural lesion as possible. Established methods to date make use of γ -emitting tracers to radio-mark the neoplastic tissue. However, in case of uptake from healthy organs around the lesion the large penetration of photons yields a non-negligible background that can limit the RGS application. The adoption of β− radiation has been proposed to overcome this limit. To validate the entire RGS procedure, from the evaluation of the tracer uptake of the tumor, to the assumptions on the bio-distribution and the signal detection, tests on ex vivo specimens of meningioma brain tumour were performed. Meningioma was selected due to the well known high receptivity to a β− emitting radio-tracer already in use in the clinical practice: 90Y-labelled DOTATOC. Patients were enrolled according to the tumour Standard Uptake Value (SUV > 2) and the expected Tumour to Non-tumour Ratio (TNR > 10) estimated from 68Ga-DOTATOC PET images. After injecting the patients with 93–167, MBq of 90Y - DOTATOC, 26 samples excised during surgery were examined with a dedicated β− detecting probe to assess the sensitivity of millimetre-sized tumour remnants in case of administration of low activity value compatible with those injected for diagnostic exams. Even injecting as low as 1.4, MBq/kg of radio-tracer, tumour remnants greater than 0.06, ml would be discriminated by the healthy tissue in few seconds.
AB - Radio-Guided Surgery (RGS) is a surgical technique aimed at assisting the surgeon to reach as complete a resection of the tumoural lesion as possible. Established methods to date make use of γ -emitting tracers to radio-mark the neoplastic tissue. However, in case of uptake from healthy organs around the lesion the large penetration of photons yields a non-negligible background that can limit the RGS application. The adoption of β− radiation has been proposed to overcome this limit. To validate the entire RGS procedure, from the evaluation of the tracer uptake of the tumor, to the assumptions on the bio-distribution and the signal detection, tests on ex vivo specimens of meningioma brain tumour were performed. Meningioma was selected due to the well known high receptivity to a β− emitting radio-tracer already in use in the clinical practice: 90Y-labelled DOTATOC. Patients were enrolled according to the tumour Standard Uptake Value (SUV > 2) and the expected Tumour to Non-tumour Ratio (TNR > 10) estimated from 68Ga-DOTATOC PET images. After injecting the patients with 93–167, MBq of 90Y - DOTATOC, 26 samples excised during surgery were examined with a dedicated β− detecting probe to assess the sensitivity of millimetre-sized tumour remnants in case of administration of low activity value compatible with those injected for diagnostic exams. Even injecting as low as 1.4, MBq/kg of radio-tracer, tumour remnants greater than 0.06, ml would be discriminated by the healthy tissue in few seconds.
KW - Intraoperative imaging
KW - Meningioma brain tumor
KW - Radioguided surgery
KW - β radiation
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U2 - 10.1007/978-981-10-9023-3_126
DO - 10.1007/978-981-10-9023-3_126
M3 - Conference article
AN - SCOPUS:85048288626
VL - 68
SP - 693
EP - 697
JO - IFMBE Proceedings
JF - IFMBE Proceedings
SN - 1680-0737
IS - 3
Y2 - 3 June 2018 through 8 June 2018
ER -