TRATTAMENTO RADIO-IPERTERMICO NELLE RECIDIVE LOCALI O LOCO-REGIONALI POST-CHIRURGICHE DA MELANOMA

Translated title of the contribution: Radio-hyperthermic treatment in the recurrence of melanoma after surgery

M. Guenzi, P. Franzone, M. P. Muttini, T. Scolaro, M. L. Rainero, E. Vigna, R. Lucchesi

Research output: Contribution to journalArticlepeer-review

Abstract

The treatment of choice of the melanoma of the skin is a radical and extensive surgical removal. Radiotherapy is useful in the advanced stages of the disease, in the presence of lymphonodes or inoperable skin nodules, or when surgery has not been radical. Melanomas are not very sensitive to radiations and require high single doses in order to obtain a relevant antitumoral effect. The association of hyperthermia and radiotherapy can improve the response. Between January 1991 and June 1992 we have treated 7 patients (6 women and one man) with local recurrence of the melanoma after surgery; 4 recurrences in the skin, two involving both skin and lymphonodes, one involving only lymphonodes. The patients aged between 40 and 88 (mean age 75 yrs). Two of them had systemic metastases at the time of the radio-hyperthermic treatment, all patients had performance status 0. The treatment consisted of 10 sessions of radiotherapy, each at the dose of 400 cGy, twice a week, the total dose amounting to 4000 cGy. Electron-beams of different energy and size have been used according to the site, extension and depth of the lesions. The hyperthermic treatment took place immediately after radiotherapy, twice a week, with a gap of 72 hours in between to prevent thermotolerance. The technique was chosen according to the depth of the lesion, with 915 MHz microwaves for superficial skin lesion and 434 MHz microwaves for deeper ones. The temperature chosen for the treatment was 42C, for 30 minutes each session, for ten sessions. All patients tolerated the treatment well. Four patients (57%) responded completely, two responded partially (29%), in one case the disease remained stable. We did not notice any relation between response and depth and diameter of the neoplasm. The duration of the response varies between 10 and 3 months (mean 4 months). None of the patients complained of important side effects. Our experience shows that radiohyperthermic treatment is effective in the local control of Melanomas of the skin.

Translated title of the contributionRadio-hyperthermic treatment in the recurrence of melanoma after surgery
Original languageItalian
Pages (from-to)221-224
Number of pages4
JournalRivista Italiana di Chirurgia Plastica
Volume25
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Surgery

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