Radio-induced gliomas: 20-year experience and critical review of the pathology

Maurizio Salvati, Alessandro D'Elia, Graziella Angelina Melone, Christian Brogna, Alessandro Frati, Antonino Raco, Roberto Delfini

Research output: Contribution to journalArticle

Abstract

The authors report their personal experience with a surgical series of 16 cases of cerebral radiation-induced gliomas, defining diagnostic criteria and surgical and clinical characteristics. There were ten males and six females, with a median age of 45.9 years. Irradiation had initially been given for acute lymphoblastic leukemia (ALL) in six cases, tinea capitis in four cases, scalp hemangioma in three cases, cutaneous hemangioma, cavernous angioma, and medulloblastoma in one case each. There were 14 cases of glioblastoma (grade IV WHO) and 2 cases of astrocytoma (grade II WHO), with a mean latency time of 17 years (range: 6-26 years). For glioblastomas mean survival time was 10.4 months, accounting for 1-3% of all the glioblastomas treated. A thorough revision of the pertinent literature revealed some clinical-biological peculiarities.

Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalJournal of Neuro-Oncology
Volume89
Issue number2
DOIs
Publication statusPublished - 2008

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Keywords

  • High grade
  • Low grade
  • Radiation-induced gliomas
  • Radiosurgery
  • Radiotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

Cite this

Salvati, M., D'Elia, A., Melone, G. A., Brogna, C., Frati, A., Raco, A., & Delfini, R. (2008). Radio-induced gliomas: 20-year experience and critical review of the pathology. Journal of Neuro-Oncology, 89(2), 169-177. https://doi.org/10.1007/s11060-008-9565-x