Radioembolization versus chemoembolization for unresectable hepatocellular carcinoma: A meta-analysis of randomized trials

Andrea Casadei Gardini, Emiliano Tamburini, Mercedes Iñarrairaegui, Giovanni Luca Frassineti, Bruno Sangro

Research output: Contribution to journalArticle

Abstract

Purpose: This study aimed to compare clinically relevant outcomes following transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) in patients with unresectable hepatocellular carcinoma (HCC) using only prospective randomized clinical trials as a source of information. Materials and methods: A meta-analysis was performed to compare the efficacy of TARE and TACE in treating patients with unresectable HCC. Only prospective randomized trials were included in the quantitative analysis. Overall and progression-free survival, disease control rate, and transplantation rate were the variables under analysis. Results: Overall survival at 1 year was similar between the two treatment groups (OR =1.31, 95% CI: 0.56–3.04, P=0.53). Progression-free survival at 1 year was also not statistically different between the two treatments (OR =0.23, 95% CI: 0.02–2.45, P=0.22). Although a higher proportion of patients underwent transplantation in the TARE group (30% vs 20.8%), this difference was not statistically significant (OR =0.68, 95% CI: 0.23–2.01; P=0.49). Conclusion: TARE and TACE provide similar outcomes in unresectable HCC. The role of TARE should be explored in selected patient subpopulations in future clinical trials.

Original languageEnglish
Pages (from-to)7315-7321
Number of pages7
JournalOncoTargets and Therapy
Volume11
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • Outcome
  • Selective internal radiation
  • SIRT
  • TACE
  • TARE
  • Transplantation rates

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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