Radiofrequency ablation of 40 lung neoplasms: Preliminary results

Cosmo Gadaleta, Vittorio Mattioli, Giuseppe Colucci, Antonio Cramarossa, Vito Lorusso, Eugenio Canniello, Artur Timurian, Girolamo Ranieri, Gianmaria Fiorentini, Mario De Lena, Annamaria Catino

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE. Radiofrequency thermal ablation is a minimally invasive treatment widely used for treatment of liver neoplasms and has also been tested on other types of tumor. Few studies have been published regarding the use of radiofrequency thermal ablation in the treatment of lung neoplasms. This study was performed to evaluate the technical feasibility, the safety, and the efficacy of lung radiofrequency thermal ablation. SUBJECTS AND METHODS. Between February 2002 and March 2003, 18 subjects with unresectable lung neoplasms, four of whom had primary neoplasms and 14 of whom had metastatic neoplasms, underwent lung radiofrequency ablation. The technique was performed percutaneously using a monopolar cooled-tip electrode needle under CT guidance with the patient under general anesthesia. Patients had no more than three nodules with a total diameter of 10 cm and no evidence of extrathoracic disease. A total of 40 nodules were treated in 24 therapeutic sessions. After treatment, patients underwent follow-up every 3 months by CT and nuclear MRI with gadolinium for a median time of 8 months (range, 2-14 months). RESULTS. No evidence of local relapse was discovered in 94.4% of subjects. The treatment was safe and well tolerated. Complications encountered included massive pneumothorax, which occurred in one subject, requiring pleural drainage. Other complications were moderate pneumothorax (also requiring pleural drainage), cough, fever, slight dyspnea, and pain, but these complications were short in duration and successfully treated. CONCLUSION. Radiofrequency thermal ablation is a promising technique in the treatment of patients with lung neoplasms and has been found to be both safe and technically feasible.

Original languageEnglish
Pages (from-to)361-368
Number of pages8
JournalAmerican Journal of Roentgenology
Volume183
Issue number2
Publication statusPublished - Aug 2004

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Lung Neoplasms
Hot Temperature
Pneumothorax
Therapeutics
Drainage
Gadolinium
Liver Neoplasms
Cough
Dyspnea
General Anesthesia
Needles
Neoplasms
Electrodes
Fever
Safety
Recurrence
Pain
Lung

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Radiofrequency ablation of 40 lung neoplasms : Preliminary results. / Gadaleta, Cosmo; Mattioli, Vittorio; Colucci, Giuseppe; Cramarossa, Antonio; Lorusso, Vito; Canniello, Eugenio; Timurian, Artur; Ranieri, Girolamo; Fiorentini, Gianmaria; De Lena, Mario; Catino, Annamaria.

In: American Journal of Roentgenology, Vol. 183, No. 2, 08.2004, p. 361-368.

Research output: Contribution to journalArticle

Gadaleta, C, Mattioli, V, Colucci, G, Cramarossa, A, Lorusso, V, Canniello, E, Timurian, A, Ranieri, G, Fiorentini, G, De Lena, M & Catino, A 2004, 'Radiofrequency ablation of 40 lung neoplasms: Preliminary results', American Journal of Roentgenology, vol. 183, no. 2, pp. 361-368.
Gadaleta C, Mattioli V, Colucci G, Cramarossa A, Lorusso V, Canniello E et al. Radiofrequency ablation of 40 lung neoplasms: Preliminary results. American Journal of Roentgenology. 2004 Aug;183(2):361-368.
Gadaleta, Cosmo ; Mattioli, Vittorio ; Colucci, Giuseppe ; Cramarossa, Antonio ; Lorusso, Vito ; Canniello, Eugenio ; Timurian, Artur ; Ranieri, Girolamo ; Fiorentini, Gianmaria ; De Lena, Mario ; Catino, Annamaria. / Radiofrequency ablation of 40 lung neoplasms : Preliminary results. In: American Journal of Roentgenology. 2004 ; Vol. 183, No. 2. pp. 361-368.
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