Radiographic evaluation of regenerated bone following poly(Lactic-Co- Glycolic) acid/hydroxyapatite and deproteinized bovine bone graft in sinus lifting

Ruggero Rodriguez y Baena, Saturnino Marco Lupi, Roberta Pastorino, Carlo Maiorana, Alessandra Lucchese, Silvana Rizzo

Research output: Contribution to journalArticle

Abstract

Although numerous biomaterials are used for maxillary sinus-lift surgery, the ideal material for such procedures has not yet been identified. Both heterologous and alloplastic bone substitutes have a solely osteoconductive effect and lack the osteoinductive properties of the bone morphogenetic proteins typical of autologous bone. Our group assessed a new alloplastic graft material, poly(lactic-co-glycolic) acid/hydroxyapatite (PLGA/HA), implanted in a human model of maxillary sinus-lift surgery. For this prospective, random, double-blind trial, we used deproteinized bovine bone (DBB) as the comparison material. Radiographic bone vertical height and density were assessed at approximately 28 weeks after grafting using cone-beam computed tomography. The vertical dimension of the regenerated bone was equivalent between the 2 groups. The density of the bone regenerated using PLGA/HA was significantly lower than that obtained with DBB. Despite clinical assessments demonstrating that PLGA/HA has sufficient characteristics for use in sinus-lift surgery, DBB provided greater bone density and an equivalent vertical dimension of grafted bone. Further studies are needed to supplement the radiologic findings with histologic and micromorphometric examinations.

Original languageEnglish
Pages (from-to)845-848
Number of pages4
JournalJournal of Craniofacial Surgery
Volume24
Issue number3
DOIs
Publication statusPublished - May 2013

Keywords

  • DBB
  • Double-blind trial
  • Human model
  • PLGA
  • Sinus lifting

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Medicine(all)

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