Abstract
Analysis of 330 exostoses in 18 patients affected by hereditary multiple exostoses disease suggested a new classification of exostoses as eccentric or full-thickness. Radiographically arrest of metaphyseal remodeling with failure of coning and persistence of the primary metaphyseal trabeculae was evident in full-thickness exostoses. Similar bone lesions can be obtained experimentally with inhibitors of bone turn-over. A localized, peripheral defect in remodeling over a limited time can give a satisfactory explanation also for the origin of eccentric exostoses. The thesis that this is the basic mechanism of exostosis formation is presented.
| Original language | English |
|---|---|
| Pages (from-to) | 594-597 |
| Number of pages | 4 |
| Journal | Pediatric Radiology |
| Volume | 20 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Oct 1990 |
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
- Radiology Nuclear Medicine and imaging
- Pediatrics, Perinatology, and Child Health
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Cite this
Pazzaglia, U. E., Pedrotti, L., Beluffi, G., Monafò, V., & Savasta, S. (1990). Radiographic findings in hereditary multiple exostoses and a new theory of the pathogenesis of exostoses. Pediatric Radiology, 20(8), 594-597. https://doi.org/10.1007/BF02129063