Radiographic findings in hereditary multiple exostoses and a new theory of the pathogenesis of exostoses

U. E. Pazzaglia, L. Pedrotti, G. Beluffi, V. Monafò, S. Savasta

Research output: Contribution to journalArticle

Abstract

Analysis of 330 exostoses in 18 patients affected by hereditary multiple exostoses disease suggested a new classification of exostoses as eccentric or full-thickness. Radiographically arrest of metaphyseal remodeling with failure of coning and persistence of the primary metaphyseal trabeculae was evident in full-thickness exostoses. Similar bone lesions can be obtained experimentally with inhibitors of bone turn-over. A localized, peripheral defect in remodeling over a limited time can give a satisfactory explanation also for the origin of eccentric exostoses. The thesis that this is the basic mechanism of exostosis formation is presented.

Original languageEnglish
Pages (from-to)594-597
Number of pages4
JournalPediatric Radiology
Volume20
Issue number8
DOIs
Publication statusPublished - Oct 1990

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health

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