Radioguided-surgery of early breast lesions

O. Buonomo, A. Cabassi, F. Guadagni, A. Piazza, A. Felici, R. Piccirillo, G. P. Atzei, C. Cipriani, S. Schiaroli, S. Mariotti, M. N. Guazzaroni, E. Cossu, G. Simonetti, E. Pernazza, C. U. Casciani, M. Roselli

Research output: Contribution to journalArticlepeer-review


Background: Radioguided-surgery has been recently proposed in patients with clinically occult breast lesions. This study aimed to evaluate the feasibility of correctly locating and eradicating, by a single intralesional injection of a radiotracer, any breast lesion and, in the case of malignancy, to perform simultaneous sentinel lymph node (SLN) biopsy procedure. Patients and Methods: Sixty-three women with early breast lesions were enrolled: 42 were invasive carcinomas, 16 in situ ductal carcinomas (DCIS) and 5 fibroadenomas. Results: Scintigraphic images clearly identified the lesions in all patients while SLN/s were evident in 88% of them. At surgery all the breast lesions were easily radiolocalized and eradicated with minimum surgical trauma and, for those patients with invasive carcinomas, the SLN technique was performed in 86% of them. No skip metastases were found. Conclusion: A single intralesional administration of radiotracer is an easy and reliable procedure to simultaneously locate and remove both the nonpalpable breast lesion and the SLN when primary malignancy was intraoperatively confirmed.

Original languageEnglish
Pages (from-to)2091-2097
Number of pages7
JournalAnticancer Research
Issue number3 C
Publication statusPublished - 2001


  • Breast cancer
  • Breast lesions
  • Radioguided surgery
  • Sentinel node

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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