Radioguided surgery with β radiation: a novel application with Ga68

Francesco Collamati, Valerio Bocci, Paolo Castellucci, Micol De Simoni, Stefano Fanti, Riccardo Faccini, Alessandro Giordano, Daria Maccora, Carlo Mancini-Terracciano, Michela Marafini, Riccardo Mirabelli, Silvio Morganti, Riccardo Schiavina, Teresa Scotognella, Giacomo Traini, Elena Solfaroli Camillocci

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Abstract

Radio Guided Surgery is a technique helping the surgeon in the resection of tumors: a radiolabeled tracer is administered to the patient before surgery and then the surgeon evaluates the completeness of the resection with a handheld detector sensitive to emitted radiation. Established methods rely on γ emitting tracers coupled with γ detecting probes. The efficacy of this technique is however hindered by the high penetration of γ radiation, limiting its applicability to low background conditions. To overtake such limitations, a novel approach to RGS has been proposed, relying on β emitting isotopes together with a dedicated β probe. This technique has been proved to be effective in first ex-vivo trials. We discuss in this paper the possibility to extend its application cases to 68Ga, a β+ emitting isotope widely used today in nuclear medicine. To this aim, a retrospective study on 45 prostatic cancer patients was performed, analysing their 68Ga-PSMA PET images to asses if the molecule uptake is enough to apply this technique. Despite the expected variability both in terms of SUV (median 4.1, IQR 3.0–6.1) and TNR (median 9.4, IQR 5.2–14.6), the majority of cases have been found to be compatible with β-RGS with reasonable injected activity and probing time (5 s).

Original languageEnglish
Article number16171
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2018

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ASJC Scopus subject areas

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Cite this

Collamati, F., Bocci, V., Castellucci, P., De Simoni, M., Fanti, S., Faccini, R., Giordano, A., Maccora, D., Mancini-Terracciano, C., Marafini, M., Mirabelli, R., Morganti, S., Schiavina, R., Scotognella, T., Traini, G., & Solfaroli Camillocci, E. (2018). Radioguided surgery with β radiation: a novel application with Ga68. Scientific Reports, 8(1), [16171]. https://doi.org/10.1038/s41598-018-34626-x