Radioguided surgery with β radiation in pancreatic Neuroendocrine Tumors: a feasibility study

Francesco Collamati, Daria Maccora, Sergio Alfieri, Valerio Bocci, Antonella Cartoni, Angela Collarino, Micol De Simoni, Marta Fischetti, Ilaria Fratoddi, Alessandro Giordano, Carlo Mancini-Terracciano, Riccardo Mirabelli, Silvio Morganti, Giuseppe Quero, Dante Rotili, Teresa Scotognella, Elena Solfaroli Camillocci, Giacomo Traini, Iole Venditti, Riccardo Faccini

Research output: Contribution to journalArticlepeer-review

Abstract

The possibility to use β decaying isotopes for radioguided surgery (RGS) has been recently proposed, and first promising tests on ex-vivo samples of Meningioma and intestinal Neuroendocrine Tumor (NET) have been published. This paper reports a study of the uptake of 68Ga-DOTATOC in pancreatic NETs (pNETs) in order to assess the feasibility of a new RGS approach using 90Y-DOTATOC. Tumor and healthy pancreas uptakes were estimated from 68Ga-DOTATOC PET/CT scans of 30 patients with pNETs. From the obtained SUVs (Standardised Uptake Value) and TNRs (Tumor Non tumor Ratio), an analysis algorithm relying on a Monte Carlo simulation of the detector has been applied to evaluate the performances of the proposed technique. Almost all considered patients resulted to be compatible with the application of β-RGS assuming to administer 1.5 MBq/kg of activity of 90Y-DOTATOC 24 h before surgery, and a sampling time of few seconds. In just 2 cases the technique would have required a mildly increased amount of activity or of sampling time. Despite a high physiological uptake of 68Ga-DOTATOC in the healthy pancreas, the proposed RGS technique promises to be effective. This approach allows RGS to find application also in pancreatic diseases, where traditional techniques are not viable.

Original languageEnglish
Article number4015
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 1 2020

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Radioguided surgery with β <sup>−</sup> radiation in pancreatic Neuroendocrine Tumors: a feasibility study'. Together they form a unique fingerprint.

Cite this