TY - JOUR
T1 - Radioimmunoguided surgery and colorectal cancer
AU - Aftab, F.
AU - Stoldt, H. S.
AU - Testori, A.
AU - Imperatori, A.
AU - Chinol, M.
AU - Paganelli, G.
AU - Geraghty, J.
PY - 1996
Y1 - 1996
N2 - Radioimmunoguided surgery is a technique that aims to delineate the extent of epithelial neoplasms (primary/recurrent) and their spread (local, regional, and distant) which are not adequately visualized by conventional imaging techniques. The target lesion binds radiolabelled, tumour-associated monoclonal antibodies which are administered in the days before surgery and which bind to the target lesion. The radiotracer is detected intraoperatively using a hand-held gamma detecting probe. This identifies the extent of the tumour, involvement of lymph nodes or other organs and may allow a more complete surgical clearance of the tumour. This article provides a basic understanding of the RIGS (radioimmunoguided surgery) technique, the monoclonal antibodies which are used and outlines the advantages and limitations of this technique.
AB - Radioimmunoguided surgery is a technique that aims to delineate the extent of epithelial neoplasms (primary/recurrent) and their spread (local, regional, and distant) which are not adequately visualized by conventional imaging techniques. The target lesion binds radiolabelled, tumour-associated monoclonal antibodies which are administered in the days before surgery and which bind to the target lesion. The radiotracer is detected intraoperatively using a hand-held gamma detecting probe. This identifies the extent of the tumour, involvement of lymph nodes or other organs and may allow a more complete surgical clearance of the tumour. This article provides a basic understanding of the RIGS (radioimmunoguided surgery) technique, the monoclonal antibodies which are used and outlines the advantages and limitations of this technique.
KW - Avidin-biotin
KW - Monoclonal antibodies
KW - Radioimmunoguided surgery
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U2 - 10.1016/S0748-7983(96)90352-2
DO - 10.1016/S0748-7983(96)90352-2
M3 - Article
C2 - 8783657
AN - SCOPUS:0029774367
VL - 22
SP - 381
EP - 388
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
SN - 0748-7983
IS - 4
ER -