Radioimmunoguided surgery and colorectal cancer

F. Aftab, H. S. Stoldt, A. Testori, A. Imperatori, M. Chinol, G. Paganelli, J. Geraghty

Research output: Contribution to journalArticlepeer-review

Abstract

Radioimmunoguided surgery is a technique that aims to delineate the extent of epithelial neoplasms (primary/recurrent) and their spread (local, regional, and distant) which are not adequately visualized by conventional imaging techniques. The target lesion binds radiolabelled, tumour-associated monoclonal antibodies which are administered in the days before surgery and which bind to the target lesion. The radiotracer is detected intraoperatively using a hand-held gamma detecting probe. This identifies the extent of the tumour, involvement of lymph nodes or other organs and may allow a more complete surgical clearance of the tumour. This article provides a basic understanding of the RIGS (radioimmunoguided surgery) technique, the monoclonal antibodies which are used and outlines the advantages and limitations of this technique.

Original languageEnglish
Pages (from-to)381-388
Number of pages8
JournalEuropean Journal of Surgical Oncology
Volume22
Issue number4
DOIs
Publication statusPublished - 1996

Keywords

  • Avidin-biotin
  • Monoclonal antibodies
  • Radioimmunoguided surgery

ASJC Scopus subject areas

  • Oncology
  • Surgery

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