Radioimmunoguided surgery with different iodine-125 radiolabeled monoclonal antibodies in recurrent colorectal cancer

Pierluigi Percivale, Sergio Bertoglio, Paolo Meszaros, Federico Schenone, Marco Gipponi, Luciano Moresco, Maurizio Cosso, Fausto Badellino

Research output: Contribution to journalArticle

Abstract

Sixty-four patients with recurrent or metastatic colorectal cancer underwent radioimmunoguided surgery (RIGS). Thirty patients (Group A) were preoperatively injected with radiolabeled monoclonal antibody (MAb) B72.3, a whole IgG1 that reacts with tumor-associated glycoprotein (TAG-72) antigen. Thirty-four patients (Group B) were given monoclonal antibody F023C5, an F(ab')2 which reacts with the carcinoembryonic antigen (CEA). The use of F(ab')2 antibodies ensured a lower time interval from the preoperative injection of the radiolabeled MAb to surgery. This interval was 22.7 days for Group A patients and 10.9 days for Group B patients. The correct RIGS identification of tumor sites occurred in 80.4% of Group A patients and in 92.6% of Group B patients. Additional information capable of modifying surgical strategy was obtained in 23.3% of Group A patients and in 8.8% of Group B patients. This difference was due to the different patterns of biodistribution and pharmacokinetics of the two MAbs. Although FO23C5 yields an improved diagnostic resolution for macroscopic tumor sites, we believe that B72.3 or other whole IgG1 should be the first choice for RIGS in recurrent or metastatic colorectal cancer patients.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalSeminars in Surgical Oncology
Volume15
Issue number4
DOIs
Publication statusPublished - Dec 1 1998

Keywords

  • Adenocarcinoma
  • Biopsy
  • Carcinoembryonic antigen
  • Colorectal neoplasms
  • False positive reactions
  • Immunohistochemistry
  • Intraoperative period
  • Iodine radioisotopes
  • Monoclonal antibodies
  • Neoplasm metastasis
  • Preoperative care
  • Radioimmunodetection
  • Radioimmunotherapy
  • Staining

ASJC Scopus subject areas

  • Surgery
  • Oncology

Fingerprint Dive into the research topics of 'Radioimmunoguided surgery with different iodine-125 radiolabeled monoclonal antibodies in recurrent colorectal cancer'. Together they form a unique fingerprint.

  • Cite this