Radioisotope assessment of heart damage in hypertransfused thalassaemic patients

F. Scopinaro, M. Banci, A. Vania, R. Tavolaro, O. Schillaci, A. Tisei, B. Werner, G. Digilio, F. Ventriglia, V. Colloridi

Research output: Contribution to journalArticle

Abstract

Twenty-five thalassaemic patients treated with repeated blood transfusion (BT) and intensive iron removal therapy were studied by echocardiography and rest/stress equilibrium gated radionuclide angiocardiography (EGNA). Stress left ventricular ejection fraction (LVEF) showed an important negative correlation with number of BTs (r = -0.75). Abnormal values of stress LVEF were measured after 200 BTs: these data demonstrate the effectiveness of stress LVEF in the follow-up of patients who have undergone repeated BTs and the clinical importance of intensive chelation therapy. Peak filling rate did not show diagnostic value in the early detection of iron cardiotoxicity. However, its inverse correlation with BT (r = -60) indicates that iron overload depresses the diastolic parameters.

Original languageEnglish
Pages (from-to)603-608
Number of pages6
JournalEuropean Journal Of Nuclear Medicine
Volume20
Issue number7
DOIs
Publication statusPublished - Jul 1993

Fingerprint

Radioisotopes
Stroke Volume
Blood Transfusion
Iron
Gated Blood-Pool Imaging
Chelation Therapy
Stress Echocardiography
Iron Overload
Therapeutics
Cardiotoxicity

Keywords

  • Ejection fraction
  • Equilibrium gated angiocardiography
  • Iron overload
  • Peak filling rate
  • Thalassaemia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Scopinaro, F., Banci, M., Vania, A., Tavolaro, R., Schillaci, O., Tisei, A., ... Colloridi, V. (1993). Radioisotope assessment of heart damage in hypertransfused thalassaemic patients. European Journal Of Nuclear Medicine, 20(7), 603-608. https://doi.org/10.1007/BF00176555

Radioisotope assessment of heart damage in hypertransfused thalassaemic patients. / Scopinaro, F.; Banci, M.; Vania, A.; Tavolaro, R.; Schillaci, O.; Tisei, A.; Werner, B.; Digilio, G.; Ventriglia, F.; Colloridi, V.

In: European Journal Of Nuclear Medicine, Vol. 20, No. 7, 07.1993, p. 603-608.

Research output: Contribution to journalArticle

Scopinaro, F, Banci, M, Vania, A, Tavolaro, R, Schillaci, O, Tisei, A, Werner, B, Digilio, G, Ventriglia, F & Colloridi, V 1993, 'Radioisotope assessment of heart damage in hypertransfused thalassaemic patients', European Journal Of Nuclear Medicine, vol. 20, no. 7, pp. 603-608. https://doi.org/10.1007/BF00176555
Scopinaro, F. ; Banci, M. ; Vania, A. ; Tavolaro, R. ; Schillaci, O. ; Tisei, A. ; Werner, B. ; Digilio, G. ; Ventriglia, F. ; Colloridi, V. / Radioisotope assessment of heart damage in hypertransfused thalassaemic patients. In: European Journal Of Nuclear Medicine. 1993 ; Vol. 20, No. 7. pp. 603-608.
@article{34108a88ecb4473cac6cacef584e16c3,
title = "Radioisotope assessment of heart damage in hypertransfused thalassaemic patients",
abstract = "Twenty-five thalassaemic patients treated with repeated blood transfusion (BT) and intensive iron removal therapy were studied by echocardiography and rest/stress equilibrium gated radionuclide angiocardiography (EGNA). Stress left ventricular ejection fraction (LVEF) showed an important negative correlation with number of BTs (r = -0.75). Abnormal values of stress LVEF were measured after 200 BTs: these data demonstrate the effectiveness of stress LVEF in the follow-up of patients who have undergone repeated BTs and the clinical importance of intensive chelation therapy. Peak filling rate did not show diagnostic value in the early detection of iron cardiotoxicity. However, its inverse correlation with BT (r = -60) indicates that iron overload depresses the diastolic parameters.",
keywords = "Ejection fraction, Equilibrium gated angiocardiography, Iron overload, Peak filling rate, Thalassaemia",
author = "F. Scopinaro and M. Banci and A. Vania and R. Tavolaro and O. Schillaci and A. Tisei and B. Werner and G. Digilio and F. Ventriglia and V. Colloridi",
year = "1993",
month = "7",
doi = "10.1007/BF00176555",
language = "English",
volume = "20",
pages = "603--608",
journal = "European Journal of Pediatrics",
issn = "0340-6199",
publisher = "Springer Berlin Heidelberg",
number = "7",

}

TY - JOUR

T1 - Radioisotope assessment of heart damage in hypertransfused thalassaemic patients

AU - Scopinaro, F.

AU - Banci, M.

AU - Vania, A.

AU - Tavolaro, R.

AU - Schillaci, O.

AU - Tisei, A.

AU - Werner, B.

AU - Digilio, G.

AU - Ventriglia, F.

AU - Colloridi, V.

PY - 1993/7

Y1 - 1993/7

N2 - Twenty-five thalassaemic patients treated with repeated blood transfusion (BT) and intensive iron removal therapy were studied by echocardiography and rest/stress equilibrium gated radionuclide angiocardiography (EGNA). Stress left ventricular ejection fraction (LVEF) showed an important negative correlation with number of BTs (r = -0.75). Abnormal values of stress LVEF were measured after 200 BTs: these data demonstrate the effectiveness of stress LVEF in the follow-up of patients who have undergone repeated BTs and the clinical importance of intensive chelation therapy. Peak filling rate did not show diagnostic value in the early detection of iron cardiotoxicity. However, its inverse correlation with BT (r = -60) indicates that iron overload depresses the diastolic parameters.

AB - Twenty-five thalassaemic patients treated with repeated blood transfusion (BT) and intensive iron removal therapy were studied by echocardiography and rest/stress equilibrium gated radionuclide angiocardiography (EGNA). Stress left ventricular ejection fraction (LVEF) showed an important negative correlation with number of BTs (r = -0.75). Abnormal values of stress LVEF were measured after 200 BTs: these data demonstrate the effectiveness of stress LVEF in the follow-up of patients who have undergone repeated BTs and the clinical importance of intensive chelation therapy. Peak filling rate did not show diagnostic value in the early detection of iron cardiotoxicity. However, its inverse correlation with BT (r = -60) indicates that iron overload depresses the diastolic parameters.

KW - Ejection fraction

KW - Equilibrium gated angiocardiography

KW - Iron overload

KW - Peak filling rate

KW - Thalassaemia

UR - http://www.scopus.com/inward/record.url?scp=0027301831&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027301831&partnerID=8YFLogxK

U2 - 10.1007/BF00176555

DO - 10.1007/BF00176555

M3 - Article

C2 - 8370381

AN - SCOPUS:0027301831

VL - 20

SP - 603

EP - 608

JO - European Journal of Pediatrics

JF - European Journal of Pediatrics

SN - 0340-6199

IS - 7

ER -