Radioisotope assessment of heart damage in hypertransfused thalassaemic patients

F. Scopinaro, M. Banci, A. Vania, R. Tavolaro, O. Schillaci, A. Tisei, B. Werner, G. Digilio, F. Ventriglia, V. Colloridi

Research output: Contribution to journalArticlepeer-review


Twenty-five thalassaemic patients treated with repeated blood transfusion (BT) and intensive iron removal therapy were studied by echocardiography and rest/stress equilibrium gated radionuclide angiocardiography (EGNA). Stress left ventricular ejection fraction (LVEF) showed an important negative correlation with number of BTs (r = -0.75). Abnormal values of stress LVEF were measured after 200 BTs: these data demonstrate the effectiveness of stress LVEF in the follow-up of patients who have undergone repeated BTs and the clinical importance of intensive chelation therapy. Peak filling rate did not show diagnostic value in the early detection of iron cardiotoxicity. However, its inverse correlation with BT (r = -60) indicates that iron overload depresses the diastolic parameters.

Original languageEnglish
Pages (from-to)603-608
Number of pages6
JournalEuropean Journal Of Nuclear Medicine
Issue number7
Publication statusPublished - Jul 1993


  • Ejection fraction
  • Equilibrium gated angiocardiography
  • Iron overload
  • Peak filling rate
  • Thalassaemia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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