Radiolabelled granulocytes in inflammatory bone disease

P. D'Amico, S. Lastoria, N. Caccavella, M. Salvatore

Research output: Contribution to journalArticlepeer-review


Inflamatory lesions in 7 patients have been investigated using labelled in vivo granulocytes. Targeting of white cells was done with a monoclonal antibody, mouse IgG1 reacting with NCA (non-specific crossreacting antigen) and CEA (carcinoembryonic antigen) (BW 250 183) labelled with 99mTc. All inflammatory lesions were visualized, with excellent quality scintigram, between 3-6 and 24 h after the injection. Because the antibody can be stored in a freeze-dried form and labelled at any time with 99mTc without cell separation being necessary, the method appears to be suitable even for use in acute diagnosis.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalInternational Journal of Radiation Applications and Instrumentation.
Issue number1
Publication statusPublished - 1991

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