Radiolabelled granulocytes in inflammatory bone disease

P. D'Amico, S. Lastoria, N. Caccavella, M. Salvatore

Research output: Contribution to journalArticle

Abstract

Inflamatory lesions in 7 patients have been investigated using labelled in vivo granulocytes. Targeting of white cells was done with a monoclonal antibody, mouse IgG1 reacting with NCA (non-specific crossreacting antigen) and CEA (carcinoembryonic antigen) (BW 250 183) labelled with 99mTc. All inflammatory lesions were visualized, with excellent quality scintigram, between 3-6 and 24 h after the injection. Because the antibody can be stored in a freeze-dried form and labelled at any time with 99mTc without cell separation being necessary, the method appears to be suitable even for use in acute diagnosis.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume18
Issue number1
DOIs
Publication statusPublished - 1991

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Cell Separation
Bone Diseases
Carcinoembryonic Antigen
Granulocytes
Immunoglobulin G
Monoclonal Antibodies
Antigens
Injections
Antibodies
BW 250 183

Cite this

Radiolabelled granulocytes in inflammatory bone disease. / D'Amico, P.; Lastoria, S.; Caccavella, N.; Salvatore, M.

In: International Journal of Radiation Applications and Instrumentation., Vol. 18, No. 1, 1991, p. 145-147.

Research output: Contribution to journalArticle

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