Abstract
A new monoclonal antibody designated FO23C5 against a protein component of carcinoembryonic antigen (CEA) has been developed. A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody (MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. We demonstrate that FO23C5 compares well with the existing anti-CEA antibody and with AUA1, and that F(ab')2 fragments perform best in achieving optimal tumour to normal tissue ratios compared with intact IgG and Fab fragment.
| Original language | English |
|---|---|
| Pages (from-to) | 259-264 |
| Number of pages | 6 |
| Journal | International Journal of Biological Markers |
| Volume | 3 |
| Issue number | 4 |
| Publication status | Published - Oct 1988 |
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ASJC Scopus subject areas
- Biochemistry
- Immunology
Cite this
Radiolocalisation of an anti-CEA monoclonal antibody (FO23C5) and its fragments in a colon carcinoma xenograft model. / Rowlinson, G.; Paganelli, G.; Snook, D.; Epenetos, A. A.
In: International Journal of Biological Markers, Vol. 3, No. 4, 10.1988, p. 259-264.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Radiolocalisation of an anti-CEA monoclonal antibody (FO23C5) and its fragments in a colon carcinoma xenograft model.
AU - Rowlinson, G.
AU - Paganelli, G.
AU - Snook, D.
AU - Epenetos, A. A.
PY - 1988/10
Y1 - 1988/10
N2 - A new monoclonal antibody designated FO23C5 against a protein component of carcinoembryonic antigen (CEA) has been developed. A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody (MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. We demonstrate that FO23C5 compares well with the existing anti-CEA antibody and with AUA1, and that F(ab')2 fragments perform best in achieving optimal tumour to normal tissue ratios compared with intact IgG and Fab fragment.
AB - A new monoclonal antibody designated FO23C5 against a protein component of carcinoembryonic antigen (CEA) has been developed. A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody (MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. We demonstrate that FO23C5 compares well with the existing anti-CEA antibody and with AUA1, and that F(ab')2 fragments perform best in achieving optimal tumour to normal tissue ratios compared with intact IgG and Fab fragment.
UR - http://www.scopus.com/inward/record.url?scp=0024102774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024102774&partnerID=8YFLogxK
M3 - Article
C2 - 3235854
AN - SCOPUS:0024102774
VL - 3
SP - 259
EP - 264
JO - International Journal of Biological Markers
JF - International Journal of Biological Markers
SN - 0393-6155
IS - 4
ER -