Abstract
A new monoclonal antibody designated FO23C5 against a protein component of carcinoembryonic antigen (CEA) has been developed. A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody (MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. We demonstrate that FO23C5 compares well with the existing anti-CEA antibody and with AUA1, and that F(ab')2 fragments perform best in achieving optimal tumour to normal tissue ratios compared with intact IgG and Fab fragment.
Original language | English |
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Pages (from-to) | 259-264 |
Number of pages | 6 |
Journal | International Journal of Biological Markers |
Volume | 3 |
Issue number | 4 |
Publication status | Published - Oct 1988 |
ASJC Scopus subject areas
- Biochemistry
- Immunology