Radiolocalisation of an anti-CEA monoclonal antibody (FO23C5) and its fragments in a colon carcinoma xenograft model.

G. Rowlinson, G. Paganelli, D. Snook, A. A. Epenetos

Research output: Contribution to journalArticlepeer-review

Abstract

A new monoclonal antibody designated FO23C5 against a protein component of carcinoembryonic antigen (CEA) has been developed. A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody (MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. We demonstrate that FO23C5 compares well with the existing anti-CEA antibody and with AUA1, and that F(ab')2 fragments perform best in achieving optimal tumour to normal tissue ratios compared with intact IgG and Fab fragment.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalInternational Journal of Biological Markers
Volume3
Issue number4
Publication statusPublished - Oct 1988

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

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