Radiolocalisation of an anti-CEA monoclonal antibody (FO23C5) and its fragments in a colon carcinoma xenograft model.

G. Rowlinson, G. Paganelli, D. Snook, A. A. Epenetos

Research output: Contribution to journalArticle

Abstract

A new monoclonal antibody designated FO23C5 against a protein component of carcinoembryonic antigen (CEA) has been developed. A xenograft system of human colon cancer was used to compare the intact monoclonal IgG with its fragments (Fab')2 and Fab) and with an established anti-CEA antibody (MAb35) and the antibody AUA1 raised against the colon carcinoma cell line. We demonstrate that FO23C5 compares well with the existing anti-CEA antibody and with AUA1, and that F(ab')2 fragments perform best in achieving optimal tumour to normal tissue ratios compared with intact IgG and Fab fragment.

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalInternational Journal of Biological Markers
Volume3
Issue number4
Publication statusPublished - Oct 1988

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Carcinoembryonic Antigen
Heterografts
Immunoglobulin Fab Fragments
Colon
Carcinoma
Antibodies
Immunoglobulin G
Colonic Neoplasms
Tumors
Cells
Tissue
Cell Line
FO23C5 monoclonal antibody
Neoplasms
Proteins

ASJC Scopus subject areas

  • Biochemistry
  • Immunology

Cite this

Radiolocalisation of an anti-CEA monoclonal antibody (FO23C5) and its fragments in a colon carcinoma xenograft model. / Rowlinson, G.; Paganelli, G.; Snook, D.; Epenetos, A. A.

In: International Journal of Biological Markers, Vol. 3, No. 4, 10.1988, p. 259-264.

Research output: Contribution to journalArticle

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