Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Andrea Sartore-Bianchi, Benedetta Mussolin, Andrea Cassingena, Cosimo Martino, Richard B. Lanman, Rebecca J. Nagy, Stephen Fairclough, Giuseppe Rospo, Giorgio Corti, Alice Bartolini, Pamela Arcella, Monica Montone, Francesca Lodi, Annalisa Lorenzato, Alice Vanzati, Emanuele Valtorta, Giovanni CappelloAndrea Bertotti, Sara Lonardi, Vittorina Zagonel, Francesco Leone, Mariangela Russo, Antonella Balsamo, Mauro Truini, Federica Di Nicolantonio, Alessio Amatu, Erica Bonazzina, Silvia Ghezzi, Daniele Regge, Angelo Vanzulli, Livio Trusolino, Salvatore Siena, Silvia Marsoni, Alberto Bardelli

Research output: Contribution to journalArticle

Abstract

Siravegna et al. identify genetic events associated with ERBB2 amplified metastatic colorectal cancers resistant to trastuzumab plus lapatinib treatment and reveal lesion-private evolutionary patterns. Analyses of metastases from a patient unveil metastasis-specific evolution and pharmacologic vulnerabilities.

Original languageEnglish
Pages (from-to)148-162.e7
JournalCancer Cell
Volume34
Issue number1
DOIs
Publication statusPublished - Jul 9 2018

Fingerprint

Colorectal Neoplasms
Neoplasm Metastasis
Therapeutics
Trastuzumab
lapatinib

Keywords

  • clonal evolution
  • colorectal cancer
  • ctDNA
  • HER2 amplification
  • lapatinib
  • liquid biopsy
  • rapid autopsy
  • resistance
  • targeted therapy
  • trastuzumab

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer. / Siravegna, Giulia; Lazzari, Luca; Crisafulli, Giovanni; Sartore-Bianchi, Andrea; Mussolin, Benedetta; Cassingena, Andrea; Martino, Cosimo; Lanman, Richard B.; Nagy, Rebecca J.; Fairclough, Stephen; Rospo, Giuseppe; Corti, Giorgio; Bartolini, Alice; Arcella, Pamela; Montone, Monica; Lodi, Francesca; Lorenzato, Annalisa; Vanzati, Alice; Valtorta, Emanuele; Cappello, Giovanni; Bertotti, Andrea; Lonardi, Sara; Zagonel, Vittorina; Leone, Francesco; Russo, Mariangela; Balsamo, Antonella; Truini, Mauro; Di Nicolantonio, Federica; Amatu, Alessio; Bonazzina, Erica; Ghezzi, Silvia; Regge, Daniele; Vanzulli, Angelo; Trusolino, Livio; Siena, Salvatore; Marsoni, Silvia; Bardelli, Alberto.

In: Cancer Cell, Vol. 34, No. 1, 09.07.2018, p. 148-162.e7.

Research output: Contribution to journalArticle

Siravegna, G, Lazzari, L, Crisafulli, G, Sartore-Bianchi, A, Mussolin, B, Cassingena, A, Martino, C, Lanman, RB, Nagy, RJ, Fairclough, S, Rospo, G, Corti, G, Bartolini, A, Arcella, P, Montone, M, Lodi, F, Lorenzato, A, Vanzati, A, Valtorta, E, Cappello, G, Bertotti, A, Lonardi, S, Zagonel, V, Leone, F, Russo, M, Balsamo, A, Truini, M, Di Nicolantonio, F, Amatu, A, Bonazzina, E, Ghezzi, S, Regge, D, Vanzulli, A, Trusolino, L, Siena, S, Marsoni, S & Bardelli, A 2018, 'Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer', Cancer Cell, vol. 34, no. 1, pp. 148-162.e7. https://doi.org/10.1016/j.ccell.2018.06.004
Siravegna, Giulia ; Lazzari, Luca ; Crisafulli, Giovanni ; Sartore-Bianchi, Andrea ; Mussolin, Benedetta ; Cassingena, Andrea ; Martino, Cosimo ; Lanman, Richard B. ; Nagy, Rebecca J. ; Fairclough, Stephen ; Rospo, Giuseppe ; Corti, Giorgio ; Bartolini, Alice ; Arcella, Pamela ; Montone, Monica ; Lodi, Francesca ; Lorenzato, Annalisa ; Vanzati, Alice ; Valtorta, Emanuele ; Cappello, Giovanni ; Bertotti, Andrea ; Lonardi, Sara ; Zagonel, Vittorina ; Leone, Francesco ; Russo, Mariangela ; Balsamo, Antonella ; Truini, Mauro ; Di Nicolantonio, Federica ; Amatu, Alessio ; Bonazzina, Erica ; Ghezzi, Silvia ; Regge, Daniele ; Vanzulli, Angelo ; Trusolino, Livio ; Siena, Salvatore ; Marsoni, Silvia ; Bardelli, Alberto. / Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer. In: Cancer Cell. 2018 ; Vol. 34, No. 1. pp. 148-162.e7.
@article{51a319115a8e41ba862ac4bff577daae,
title = "Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer",
abstract = "Siravegna et al. identify genetic events associated with ERBB2 amplified metastatic colorectal cancers resistant to trastuzumab plus lapatinib treatment and reveal lesion-private evolutionary patterns. Analyses of metastases from a patient unveil metastasis-specific evolution and pharmacologic vulnerabilities.",
keywords = "clonal evolution, colorectal cancer, ctDNA, HER2 amplification, lapatinib, liquid biopsy, rapid autopsy, resistance, targeted therapy, trastuzumab",
author = "Giulia Siravegna and Luca Lazzari and Giovanni Crisafulli and Andrea Sartore-Bianchi and Benedetta Mussolin and Andrea Cassingena and Cosimo Martino and Lanman, {Richard B.} and Nagy, {Rebecca J.} and Stephen Fairclough and Giuseppe Rospo and Giorgio Corti and Alice Bartolini and Pamela Arcella and Monica Montone and Francesca Lodi and Annalisa Lorenzato and Alice Vanzati and Emanuele Valtorta and Giovanni Cappello and Andrea Bertotti and Sara Lonardi and Vittorina Zagonel and Francesco Leone and Mariangela Russo and Antonella Balsamo and Mauro Truini and {Di Nicolantonio}, Federica and Alessio Amatu and Erica Bonazzina and Silvia Ghezzi and Daniele Regge and Angelo Vanzulli and Livio Trusolino and Salvatore Siena and Silvia Marsoni and Alberto Bardelli",
year = "2018",
month = "7",
day = "9",
doi = "10.1016/j.ccell.2018.06.004",
language = "English",
volume = "34",
pages = "148--162.e7",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

AU - Siravegna, Giulia

AU - Lazzari, Luca

AU - Crisafulli, Giovanni

AU - Sartore-Bianchi, Andrea

AU - Mussolin, Benedetta

AU - Cassingena, Andrea

AU - Martino, Cosimo

AU - Lanman, Richard B.

AU - Nagy, Rebecca J.

AU - Fairclough, Stephen

AU - Rospo, Giuseppe

AU - Corti, Giorgio

AU - Bartolini, Alice

AU - Arcella, Pamela

AU - Montone, Monica

AU - Lodi, Francesca

AU - Lorenzato, Annalisa

AU - Vanzati, Alice

AU - Valtorta, Emanuele

AU - Cappello, Giovanni

AU - Bertotti, Andrea

AU - Lonardi, Sara

AU - Zagonel, Vittorina

AU - Leone, Francesco

AU - Russo, Mariangela

AU - Balsamo, Antonella

AU - Truini, Mauro

AU - Di Nicolantonio, Federica

AU - Amatu, Alessio

AU - Bonazzina, Erica

AU - Ghezzi, Silvia

AU - Regge, Daniele

AU - Vanzulli, Angelo

AU - Trusolino, Livio

AU - Siena, Salvatore

AU - Marsoni, Silvia

AU - Bardelli, Alberto

PY - 2018/7/9

Y1 - 2018/7/9

N2 - Siravegna et al. identify genetic events associated with ERBB2 amplified metastatic colorectal cancers resistant to trastuzumab plus lapatinib treatment and reveal lesion-private evolutionary patterns. Analyses of metastases from a patient unveil metastasis-specific evolution and pharmacologic vulnerabilities.

AB - Siravegna et al. identify genetic events associated with ERBB2 amplified metastatic colorectal cancers resistant to trastuzumab plus lapatinib treatment and reveal lesion-private evolutionary patterns. Analyses of metastases from a patient unveil metastasis-specific evolution and pharmacologic vulnerabilities.

KW - clonal evolution

KW - colorectal cancer

KW - ctDNA

KW - HER2 amplification

KW - lapatinib

KW - liquid biopsy

KW - rapid autopsy

KW - resistance

KW - targeted therapy

KW - trastuzumab

UR - http://www.scopus.com/inward/record.url?scp=85048975846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048975846&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2018.06.004

DO - 10.1016/j.ccell.2018.06.004

M3 - Article

AN - SCOPUS:85048975846

VL - 34

SP - 148-162.e7

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 1

ER -