Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Giulia Siravegna; Luca Lazzari; Giovanni Crisafulli; Andrea Sartore-Bianchi; Benedetta Mussolin; Andrea Cassingena; Cosimo Martino; Richard B. Lanman; Rebecca J. Nagy; Stephen Fairclough; Giuseppe Rospo; Giorgio Corti; Alice Bartolini; Pamela Arcella; Monica Montone; Francesca Lodi; Annalisa Lorenzato; Alice Vanzati; Emanuele Valtorta; Giovanni Cappello; Andrea Bertotti; Sara Lonardi; Vittorina Zagonel; Francesco Leone; Mariangela Russo; Antonella Balsamo; Mauro Truini; Federica Di Nicolantonio; Alessio Amatu; Erica Bonazzina; Silvia Ghezzi; Daniele Regge; Angelo Vanzulli; Livio Trusolino; Salvatore Siena; Silvia Marsoni; Alberto Bardelli

doi:10.1016/j.ccell.2018.06.004

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Giulia Siravegna, Luca Lazzari, Giovanni Crisafulli, Andrea Sartore-Bianchi, Benedetta Mussolin, Andrea Cassingena, Cosimo Martino, Richard B. Lanman, Rebecca J. Nagy, Stephen Fairclough, Giuseppe Rospo, Giorgio Corti, Alice Bartolini, Pamela Arcella, Monica Montone, Francesca Lodi, Annalisa Lorenzato, Alice Vanzati, Emanuele Valtorta, Giovanni CappelloAndrea Bertotti, Sara Lonardi, Vittorina Zagonel, Francesco Leone, Mariangela Russo, Antonella Balsamo, Mauro Truini, Federica Di Nicolantonio, Alessio Amatu, Erica Bonazzina, Silvia Ghezzi, Daniele Regge, Angelo Vanzulli, Livio Trusolino, Salvatore Siena, Silvia Marsoni, Alberto Bardelli

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Siravegna et al. identify genetic events associated with ERBB2 amplified metastatic colorectal cancers resistant to trastuzumab plus lapatinib treatment and reveal lesion-private evolutionary patterns. Analyses of metastases from a patient unveil metastasis-specific evolution and pharmacologic vulnerabilities.

Original language	English
Pages (from-to)	148-162.e7
Journal	Cancer Cell
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.ccell.2018.06.004
Publication status	Published - Jul 9 2018

Keywords

clonal evolution
colorectal cancer
ctDNA
HER2 amplification
lapatinib
liquid biopsy
rapid autopsy
resistance
targeted therapy
trastuzumab

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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10.1016/j.ccell.2018.06.004

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Siravegna, G., Lazzari, L., Crisafulli, G., Sartore-Bianchi, A., Mussolin, B., Cassingena, A., Martino, C., Lanman, R. B., Nagy, R. J., Fairclough, S., Rospo, G., Corti, G., Bartolini, A., Arcella, P., Montone, M., Lodi, F., Lorenzato, A., Vanzati, A., Valtorta, E., ... Bardelli, A. (2018). Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer. Cancer Cell, 34(1), 148-162.e7. https://doi.org/10.1016/j.ccell.2018.06.004

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer. / Siravegna, Giulia; Lazzari, Luca; Crisafulli, Giovanni; Sartore-Bianchi, Andrea; Mussolin, Benedetta; Cassingena, Andrea; Martino, Cosimo; Lanman, Richard B.; Nagy, Rebecca J.; Fairclough, Stephen; Rospo, Giuseppe ; Corti, Giorgio ; Bartolini, Alice; Arcella, Pamela; Montone, Monica; Lodi, Francesca; Lorenzato, Annalisa; Vanzati, Alice; Valtorta, Emanuele; Cappello, Giovanni; Bertotti, Andrea; Lonardi, Sara; Zagonel, Vittorina; Leone, Francesco; Russo, Mariangela ; Balsamo, Antonella; Truini, Mauro; Di Nicolantonio, Federica; Amatu, Alessio; Bonazzina, Erica; Ghezzi, Silvia; Regge, Daniele; Vanzulli, Angelo; Trusolino, Livio; Siena, Salvatore; Marsoni, Silvia; Bardelli, Alberto.

In: Cancer Cell, Vol. 34, No. 1, 09.07.2018, p. 148-162.e7.

Research output: Contribution to journal › Article › peer-review

Siravegna, G, Lazzari, L, Crisafulli, G, Sartore-Bianchi, A, Mussolin, B, Cassingena, A, Martino, C, Lanman, RB, Nagy, RJ, Fairclough, S, Rospo, G , Corti, G , Bartolini, A, Arcella, P, Montone, M, Lodi, F, Lorenzato, A, Vanzati, A, Valtorta, E, Cappello, G, Bertotti, A, Lonardi, S, Zagonel, V, Leone, F, Russo, M , Balsamo, A, Truini, M, Di Nicolantonio, F, Amatu, A, Bonazzina, E, Ghezzi, S, Regge, D, Vanzulli, A, Trusolino, L, Siena, S, Marsoni, S & Bardelli, A 2018, 'Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer', Cancer Cell, vol. 34, no. 1, pp. 148-162.e7. https://doi.org/10.1016/j.ccell.2018.06.004

Siravegna, Giulia ; Lazzari, Luca ; Crisafulli, Giovanni ; Sartore-Bianchi, Andrea ; Mussolin, Benedetta ; Cassingena, Andrea ; Martino, Cosimo ; Lanman, Richard B. ; Nagy, Rebecca J. ; Fairclough, Stephen ; Rospo, Giuseppe ; Corti, Giorgio ; Bartolini, Alice ; Arcella, Pamela ; Montone, Monica ; Lodi, Francesca ; Lorenzato, Annalisa ; Vanzati, Alice ; Valtorta, Emanuele ; Cappello, Giovanni ; Bertotti, Andrea ; Lonardi, Sara ; Zagonel, Vittorina ; Leone, Francesco ; Russo, Mariangela ; Balsamo, Antonella ; Truini, Mauro ; Di Nicolantonio, Federica ; Amatu, Alessio ; Bonazzina, Erica ; Ghezzi, Silvia ; Regge, Daniele ; Vanzulli, Angelo ; Trusolino, Livio ; Siena, Salvatore ; Marsoni, Silvia ; Bardelli, Alberto. / Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer. In: Cancer Cell. 2018 ; Vol. 34, No. 1. pp. 148-162.e7.

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title = "Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer",

abstract = "Siravegna et al. identify genetic events associated with ERBB2 amplified metastatic colorectal cancers resistant to trastuzumab plus lapatinib treatment and reveal lesion-private evolutionary patterns. Analyses of metastases from a patient unveil metastasis-specific evolution and pharmacologic vulnerabilities.",

keywords = "clonal evolution, colorectal cancer, ctDNA, HER2 amplification, lapatinib, liquid biopsy, rapid autopsy, resistance, targeted therapy, trastuzumab",

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AU - Mussolin, Benedetta

AU - Cassingena, Andrea

AU - Martino, Cosimo

AU - Lanman, Richard B.

AU - Nagy, Rebecca J.

AU - Fairclough, Stephen

AU - Rospo, Giuseppe

AU - Corti, Giorgio

AU - Bartolini, Alice

AU - Arcella, Pamela

AU - Montone, Monica

AU - Lodi, Francesca

AU - Lorenzato, Annalisa

AU - Vanzati, Alice

AU - Valtorta, Emanuele

AU - Cappello, Giovanni

AU - Bertotti, Andrea

AU - Lonardi, Sara

AU - Zagonel, Vittorina

AU - Leone, Francesco

AU - Russo, Mariangela

AU - Balsamo, Antonella

AU - Truini, Mauro

AU - Di Nicolantonio, Federica

AU - Amatu, Alessio

AU - Bonazzina, Erica

AU - Ghezzi, Silvia

AU - Regge, Daniele

AU - Vanzulli, Angelo

AU - Trusolino, Livio

AU - Siena, Salvatore

AU - Marsoni, Silvia

AU - Bardelli, Alberto

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Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer

Abstract

Keywords

ASJC Scopus subject areas

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