Radiological exposure of patients undergoing transcatheter aortic valve implantation in contemporary practice

Luigi Biasco, Giovanni Pedrazzini, Ole De Backer, Catherine Klersy, Luca Bellesi, Stefano Presilla, Matteo Badini, Francesco Faletra, Elena Pasotti, Enrico Ferrari, Stefanos Demertzis, Tiziano Moccetti, Davide Aviano, Marco Moccetti

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Abstract

BACKGROUND: Radiological exposure associated with transcatheter aortic valve implantation (TAVI) is unknown and might impact on broadening indications to lower risk patients. Radiological exposure of TAVI patients and its predictors are herein reported.

METHODS: Radiological exposure derived from exams/procedures performed within 30 days preceding/following TAVI were acquired and converted into effective-dose. Total effective-dose was defined as the sum of each single dose derived from diagnostic/therapeutic sources. Univariable and multivariable analyses were performed to recognize correlates of exposure.

RESULTS: Seventy-five patients aged 82.6 ± 6.0 years with a median Euroscore II 3.6 [IQR 1.93-6.65] were analysed. Median total effective-dose was 41.39 mSv [IQR 27.93-60.88], with TAVI accounting for 47% of it. Age (coefficient -0.031, 95% CI -0.060 to -0.002; P = 0.031) and previous history of cerebrovascular accidents (CVA; coefficient -0.545; 95% CI -1.039 to -0.010; P = 0.046) resulted as inversely correlated to total effective-dose (log-transformed), whereas left ventricular ejection fraction (LVEF) less than 50% (coefficient 0.430, 95% CI 0.031-0.828; P = 0.035) was directly associated.

CONCLUSION: Multiple radiological sources are responsible for the observed exposure, with TAVI being the prominent source. Age is inversely related to the radiological exposure.

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalJournal of cardiovascular medicine (Hagerstown, Md.)
Volume19
Issue number10
DOIs
Publication statusPublished - Oct 2018

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Radiological exposure of patients undergoing transcatheter aortic valve implantation in contemporary practice. / Biasco, Luigi; Pedrazzini, Giovanni; De Backer, Ole; Klersy, Catherine; Bellesi, Luca; Presilla, Stefano; Badini, Matteo; Faletra, Francesco; Pasotti, Elena; Ferrari, Enrico; Demertzis, Stefanos; Moccetti, Tiziano; Aviano, Davide; Moccetti, Marco.

In: Journal of cardiovascular medicine (Hagerstown, Md.), Vol. 19, No. 10, 10.2018, p. 579-585.

Research output: Contribution to journalArticle

Biasco, L, Pedrazzini, G, De Backer, O, Klersy, C, Bellesi, L, Presilla, S, Badini, M, Faletra, F, Pasotti, E, Ferrari, E, Demertzis, S, Moccetti, T, Aviano, D & Moccetti, M 2018, 'Radiological exposure of patients undergoing transcatheter aortic valve implantation in contemporary practice', Journal of cardiovascular medicine (Hagerstown, Md.), vol. 19, no. 10, pp. 579-585. https://doi.org/10.2459/JCM.0000000000000692
Biasco, Luigi ; Pedrazzini, Giovanni ; De Backer, Ole ; Klersy, Catherine ; Bellesi, Luca ; Presilla, Stefano ; Badini, Matteo ; Faletra, Francesco ; Pasotti, Elena ; Ferrari, Enrico ; Demertzis, Stefanos ; Moccetti, Tiziano ; Aviano, Davide ; Moccetti, Marco. / Radiological exposure of patients undergoing transcatheter aortic valve implantation in contemporary practice. In: Journal of cardiovascular medicine (Hagerstown, Md.). 2018 ; Vol. 19, No. 10. pp. 579-585.
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abstract = "BACKGROUND: Radiological exposure associated with transcatheter aortic valve implantation (TAVI) is unknown and might impact on broadening indications to lower risk patients. Radiological exposure of TAVI patients and its predictors are herein reported.METHODS: Radiological exposure derived from exams/procedures performed within 30 days preceding/following TAVI were acquired and converted into effective-dose. Total effective-dose was defined as the sum of each single dose derived from diagnostic/therapeutic sources. Univariable and multivariable analyses were performed to recognize correlates of exposure.RESULTS: Seventy-five patients aged 82.6 ± 6.0 years with a median Euroscore II 3.6 [IQR 1.93-6.65] were analysed. Median total effective-dose was 41.39 mSv [IQR 27.93-60.88], with TAVI accounting for 47{\%} of it. Age (coefficient -0.031, 95{\%} CI -0.060 to -0.002; P = 0.031) and previous history of cerebrovascular accidents (CVA; coefficient -0.545; 95{\%} CI -1.039 to -0.010; P = 0.046) resulted as inversely correlated to total effective-dose (log-transformed), whereas left ventricular ejection fraction (LVEF) less than 50{\%} (coefficient 0.430, 95{\%} CI 0.031-0.828; P = 0.035) was directly associated.CONCLUSION: Multiple radiological sources are responsible for the observed exposure, with TAVI being the prominent source. Age is inversely related to the radiological exposure.",
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T1 - Radiological exposure of patients undergoing transcatheter aortic valve implantation in contemporary practice

AU - Biasco, Luigi

AU - Pedrazzini, Giovanni

AU - De Backer, Ole

AU - Klersy, Catherine

AU - Bellesi, Luca

AU - Presilla, Stefano

AU - Badini, Matteo

AU - Faletra, Francesco

AU - Pasotti, Elena

AU - Ferrari, Enrico

AU - Demertzis, Stefanos

AU - Moccetti, Tiziano

AU - Aviano, Davide

AU - Moccetti, Marco

PY - 2018/10

Y1 - 2018/10

N2 - BACKGROUND: Radiological exposure associated with transcatheter aortic valve implantation (TAVI) is unknown and might impact on broadening indications to lower risk patients. Radiological exposure of TAVI patients and its predictors are herein reported.METHODS: Radiological exposure derived from exams/procedures performed within 30 days preceding/following TAVI were acquired and converted into effective-dose. Total effective-dose was defined as the sum of each single dose derived from diagnostic/therapeutic sources. Univariable and multivariable analyses were performed to recognize correlates of exposure.RESULTS: Seventy-five patients aged 82.6 ± 6.0 years with a median Euroscore II 3.6 [IQR 1.93-6.65] were analysed. Median total effective-dose was 41.39 mSv [IQR 27.93-60.88], with TAVI accounting for 47% of it. Age (coefficient -0.031, 95% CI -0.060 to -0.002; P = 0.031) and previous history of cerebrovascular accidents (CVA; coefficient -0.545; 95% CI -1.039 to -0.010; P = 0.046) resulted as inversely correlated to total effective-dose (log-transformed), whereas left ventricular ejection fraction (LVEF) less than 50% (coefficient 0.430, 95% CI 0.031-0.828; P = 0.035) was directly associated.CONCLUSION: Multiple radiological sources are responsible for the observed exposure, with TAVI being the prominent source. Age is inversely related to the radiological exposure.

AB - BACKGROUND: Radiological exposure associated with transcatheter aortic valve implantation (TAVI) is unknown and might impact on broadening indications to lower risk patients. Radiological exposure of TAVI patients and its predictors are herein reported.METHODS: Radiological exposure derived from exams/procedures performed within 30 days preceding/following TAVI were acquired and converted into effective-dose. Total effective-dose was defined as the sum of each single dose derived from diagnostic/therapeutic sources. Univariable and multivariable analyses were performed to recognize correlates of exposure.RESULTS: Seventy-five patients aged 82.6 ± 6.0 years with a median Euroscore II 3.6 [IQR 1.93-6.65] were analysed. Median total effective-dose was 41.39 mSv [IQR 27.93-60.88], with TAVI accounting for 47% of it. Age (coefficient -0.031, 95% CI -0.060 to -0.002; P = 0.031) and previous history of cerebrovascular accidents (CVA; coefficient -0.545; 95% CI -1.039 to -0.010; P = 0.046) resulted as inversely correlated to total effective-dose (log-transformed), whereas left ventricular ejection fraction (LVEF) less than 50% (coefficient 0.430, 95% CI 0.031-0.828; P = 0.035) was directly associated.CONCLUSION: Multiple radiological sources are responsible for the observed exposure, with TAVI being the prominent source. Age is inversely related to the radiological exposure.

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DO - 10.2459/JCM.0000000000000692

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JO - Journal of Cardiovascular Medicine

JF - Journal of Cardiovascular Medicine

SN - 1558-2027

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