Radionuclide monitoring of cardiac adaptations to volume loading in patients with dilated cardiomyopathy and mild heart failure: Effects of angiotensin-converting enzyme inhibition

M. Volpe, M. A E Rao, A. Cuocolo, R. Russo, A. Nappi, A. F. Mele, I. Enea, B. Trimarco, M. Condorelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Cardiac adaptations to volume overload have been poorly investigated in heart failure. The aim of this study was to assess dynamic left ventricular responses to acute volume loading by continuous radionuclide monitoring in patients with asymptomatic to mildly symptomatic left ventricular dysfunction. Methods and Results: Left ventricular end-diastolic (EDV) and end-systolic (ESV) volumes, ejection fraction (EF), and peak filling rate (PFR) were monitored by a radionuclide detector (Vest) before and during volume expansion (sodium chloride, 0.9%, 0.25 mL · kg-1 · min-1 for 2 hours) in 10 patients with idiopathic dilated cardiomyopathy (DCM) and mild heart failure (New York Heart Association class I or II, ejection fraction

Original languageEnglish
Pages (from-to)2511-2518
Number of pages8
JournalCirculation
Volume92
Issue number9
Publication statusPublished - 1995

Keywords

  • cardiomyopathy
  • radioisotopes
  • ventricles

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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