Radioprotective action of haematoporphyrin on X-irradiated trypsin

V. Pistoia, Carmela Murolo

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Abstract

Dose-response curves were obtained for trypsin X-irradiated in aqueous solution (4.6×10-6M), alone or after incubation with haematoporphyrin (Hp). When trypsin was irradiated alone (exposure doses ranging from 10 to 25 kR) the exponential dose-response curve showed a D37 equal to 17200 R. When trypsin was incubated with Hp before irradiation a D37 equal to 61900 R was obtained, with a dose reduction factor of 3.6. Therefore in our experimental conditions Hp shows a highly significant radioprotective action.

Original languageEnglish
Pages (from-to)873-874
Number of pages2
JournalExperientia
Volume36
Issue number7
DOIs
Publication statusPublished - Jul 1980

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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