Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Piero Picozzi; Marco Losa; Pietro Mortini; Micol Angela Valle; Alberto Franzin; Luca Attuati; Camillo Ferrari Da Passano; Massimo Giovanelli

doi:10.3171/jns.2005.102.s_supplement.0071

Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Piero Picozzi, Marco Losa, Pietro Mortini, Micol Angela Valle, Alberto Franzin, Luca Attuati, Camillo Ferrari Da Passano, Massimo Giovanelli

Research output: Contribution to journal › Article › peer-review

Abstract

Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm ³ to 1.6 ± 0.2 cm ³ at last follow up (p

Original language	English
Pages (from-to)	71-74
Number of pages	4
Journal	Journal of Neurosurgery
Volume	102
Issue number	SUPPL.
DOIs	https://doi.org/10.3171/jns.2005.102.s_supplement.0071
Publication status	Published - Jan 2005

Keywords

Gamma knife surgery
Nonfunctioning pituitary adenoma
Pituitary

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Access to Document

10.3171/jns.2005.102.s_supplement.0071

Fingerprint Dive into the research topics of 'Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas'. Together they form a unique fingerprint.

Cite this

Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. / Picozzi, Piero ; Losa, Marco ; Mortini, Pietro; Valle, Micol Angela; Franzin, Alberto; Attuati, Luca; Da Passano, Camillo Ferrari; Giovanelli, Massimo.

In: Journal of Neurosurgery, Vol. 102, No. SUPPL., 01.2005, p. 71-74.

Research output: Contribution to journal › Article › peer-review

@article{42b4a00e186b4136b518708e96520c8e,

title = "Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas",

abstract = "Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p ",

keywords = "Gamma knife surgery, Nonfunctioning pituitary adenoma, Pituitary",

author = "Piero Picozzi and Marco Losa and Pietro Mortini and Valle, {Micol Angela} and Alberto Franzin and Luca Attuati and {Da Passano}, {Camillo Ferrari} and Massimo Giovanelli",

year = "2005",

month = jan,

doi = "10.3171/jns.2005.102.s_supplement.0071",

language = "English",

volume = "102",

pages = "71--74",

journal = "Journal of Neurosurgery",

issn = "0022-3085",

publisher = "American Association of Neurological Surgeons",

number = "SUPPL.",

}

TY - JOUR

T1 - Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

AU - Picozzi, Piero

AU - Losa, Marco

AU - Mortini, Pietro

AU - Valle, Micol Angela

AU - Franzin, Alberto

AU - Attuati, Luca

AU - Da Passano, Camillo Ferrari

AU - Giovanelli, Massimo

PY - 2005/1

Y1 - 2005/1

N2 - Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p

AB - Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p

KW - Gamma knife surgery

KW - Nonfunctioning pituitary adenoma

KW - Pituitary

UR - http://www.scopus.com/inward/record.url?scp=13744252461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13744252461&partnerID=8YFLogxK

U2 - 10.3171/jns.2005.102.s_supplement.0071

DO - 10.3171/jns.2005.102.s_supplement.0071

M3 - Article

C2 - 15662784

AN - SCOPUS:13744252461

VL - 102

SP - 71

EP - 74

JO - Journal of Neurosurgery

JF - Journal of Neurosurgery

SN - 0022-3085

IS - SUPPL.

ER -

Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this