Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Piero Picozzi; Marco Losa; Pietro Mortini; Micol Angela Valle; Alberto Franzin; Luca Attuati; Camillo Ferrari Da Passano; Massimo Giovanelli

doi:10.3171/jns.2005.102.s_supplement.0071

Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Piero Picozzi, Marco Losa, Pietro Mortini, Micol Angela Valle, Alberto Franzin, Luca Attuati, Camillo Ferrari Da Passano, Massimo Giovanelli

Research output: Contribution to journal › Article › peer-review

Abstract

Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm ³ to 1.6 ± 0.2 cm ³ at last follow up (p

Original language	English
Pages (from-to)	71-74
Number of pages	4
Journal	Journal of Neurosurgery
Volume	102
Issue number	SUPPL.
DOIs	https://doi.org/10.3171/jns.2005.102.s_supplement.0071
Publication status	Published - Jan 2005

Keywords

Gamma knife surgery
Nonfunctioning pituitary adenoma
Pituitary

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

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10.3171/jns.2005.102.s_supplement.0071

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title = "Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas",

abstract = "Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p ",

keywords = "Gamma knife surgery, Nonfunctioning pituitary adenoma, Pituitary",

author = "Piero Picozzi and Marco Losa and Pietro Mortini and Valle, {Micol Angela} and Alberto Franzin and Luca Attuati and {Da Passano}, {Camillo Ferrari} and Massimo Giovanelli",

year = "2005",

month = jan,

doi = "10.3171/jns.2005.102.s_supplement.0071",

language = "English",

volume = "102",

pages = "71--74",

journal = "Journal of Neurosurgery",

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publisher = "American Association of Neurological Surgeons",

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AU - Picozzi, Piero

AU - Losa, Marco

AU - Mortini, Pietro

AU - Valle, Micol Angela

AU - Franzin, Alberto

AU - Attuati, Luca

AU - Da Passano, Camillo Ferrari

AU - Giovanelli, Massimo

PY - 2005/1

Y1 - 2005/1

N2 - Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p

AB - Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p

KW - Gamma knife surgery

KW - Nonfunctioning pituitary adenoma

KW - Pituitary

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Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Abstract

Keywords

ASJC Scopus subject areas

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