Abstract
Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p
| Original language | English |
|---|---|
| Pages (from-to) | 71-74 |
| Number of pages | 4 |
| Journal | Journal of Neurosurgery |
| Volume | 102 |
| Issue number | SUPPL. |
| DOIs | |
| Publication status | Published - Jan 2005 |
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Keywords
- Gamma knife surgery
- Nonfunctioning pituitary adenoma
- Pituitary
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. / Picozzi, Piero; Losa, Marco; Mortini, Pietro; Valle, Micol Angela; Franzin, Alberto; Attuati, Luca; Da Passano, Camillo Ferrari; Giovanelli, Massimo.
In: Journal of Neurosurgery, Vol. 102, No. SUPPL., 01.2005, p. 71-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas
AU - Picozzi, Piero
AU - Losa, Marco
AU - Mortini, Pietro
AU - Valle, Micol Angela
AU - Franzin, Alberto
AU - Attuati, Luca
AU - Da Passano, Camillo Ferrari
AU - Giovanelli, Massimo
PY - 2005/1
Y1 - 2005/1
N2 - Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p
AB - Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p
KW - Gamma knife surgery
KW - Nonfunctioning pituitary adenoma
KW - Pituitary
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UR - http://www.scopus.com/inward/citedby.url?scp=13744252461&partnerID=8YFLogxK
U2 - 10.3171/jns.2005.102.s_supplement.0071
DO - 10.3171/jns.2005.102.s_supplement.0071
M3 - Article
VL - 102
SP - 71
EP - 74
JO - Journal of Neurosurgery
JF - Journal of Neurosurgery
SN - 0022-3085
IS - SUPPL.
ER -