Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Piero Picozzi; Marco Losa; Pietro Mortini; Micol Angela Valle; Alberto Franzin; Luca Attuati; Camillo Ferrari Da Passano; Massimo Giovanelli

doi:10.3171/jns.2005.102.s_supplement.0071

Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Piero Picozzi, Marco Losa, Pietro Mortini, Micol Angela Valle, Alberto Franzin, Luca Attuati, Camillo Ferrari Da Passano, Massimo Giovanelli

Research output: Contribution to journal › Article

Abstract

Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm ³ to 1.6 ± 0.2 cm ³ at last follow up (p

Original language	English
Pages (from-to)	71-74
Number of pages	4
Journal	Journal of Neurosurgery
Volume	102
Issue number	SUPPL.
DOIs	https://doi.org/10.3171/jns.2005.102.s_supplement.0071
Publication status	Published - Jan 2005

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Keywords

Gamma knife surgery
Nonfunctioning pituitary adenoma
Pituitary

ASJC Scopus subject areas

Clinical Neurology
Neuroscience(all)

Cite this

Picozzi, P., Losa, M., Mortini, P., Valle, M. A., Franzin, A., Attuati, L., Da Passano, C. F., & Giovanelli, M. (2005). Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. Journal of Neurosurgery, 102(SUPPL.), 71-74. https://doi.org/10.3171/jns.2005.102.s_supplement.0071

Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas. / Picozzi, Piero ; Losa, Marco ; Mortini, Pietro; Valle, Micol Angela; Franzin, Alberto; Attuati, Luca; Da Passano, Camillo Ferrari; Giovanelli, Massimo.

In: Journal of Neurosurgery, Vol. 102, No. SUPPL., 01.2005, p. 71-74.

Research output: Contribution to journal › Article

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abstract = "Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p ",

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