Radiosurgery and the prevention of regrowth of incompletely removed nonfunctioning pituitary adenomas

Piero Picozzi, Marco Losa, Pietro Mortini, Micol Angela Valle, Alberto Franzin, Luca Attuati, Camillo Ferrari Da Passano, Massimo Giovanelli

Research output: Contribution to journalArticlepeer-review


Object. The authors studied the efficacy of gamma knife radiosurgery (GKS) in the prevention of regrowth of nonfunctioning pituitary adenomas (NPA). Methods. One hundred nineteen patients were included in this study and were divided into two groups. All patients had undergone surgery in our department and recurrent or residual adenoma was demonstrated on postoperative MR imaging. Group A consisted of 68 patients who were followed without additional treatment. Group B was composed of 51 patients who received GKS within 1 year after microsurgery. There was no significant demographic difference between the two groups. In Group B the mean margin dose was 16.5 ± 0.3 Gy (range 13-21 Gy). Fifty one and one tenth percent of patients in Group A were recurrence free at 5 years and 89.8% in Group B (p <0.001). In Group B patients, tumor volume decreased from a baseline value of 2.4 ± 0.2 cm 3 to 1.6 ± 0.2 cm 3 at last follow up (p

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalJournal of Neurosurgery
Issue numberSUPPL.
Publication statusPublished - Jan 2005


  • Gamma knife surgery
  • Nonfunctioning pituitary adenoma
  • Pituitary

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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