Radiosynthesis of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography

Thomas Chaly, Vijay Dhawan, Ken Kazumata, Angelo Antonini, Claude Margouleff, J. Robert Dahl, Abdelfatihe Belakhlef, Donald Margouleff, Archie Yee, Shaoyin Wang, Gilles Tamagnan, John L. Neumeyer, David Eidelberg

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

A procedure for the routine preparation of [18F]FP-CIT has been developed. Purification of the final product was achieved by preparative HPLC using phenethyl column without decomposition or epimerization. [18F] labeled-N-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane was prepared and PET imaging was performed on human subjects. A high uptake into striatal regions was observed. HPLC plasma analysis using [18F]FP-CIT indicated the presence of only one metabolite. By directly comparing the behavior of these three radiotracers ([18F]DOPA, [123I]FP-CIT, and [18F]FP-CIT) in the same subjects, we can enhance our understanding of the dopaminergic system as well as the relative potential of these techniques in a clinical research setting.

Original languageEnglish
Pages (from-to)999-1004
Number of pages6
JournalNuclear Medicine and Biology
Volume23
Issue number8
DOIs
Publication statusPublished - Nov 1996

Fingerprint

Nortropanes
Positron-Emission Tomography
High Pressure Liquid Chromatography
Corpus Striatum
2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane
Research

Keywords

  • dopamine transporter imaging
  • FP-CIT
  • PET

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Radiosynthesis of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography. / Chaly, Thomas; Dhawan, Vijay; Kazumata, Ken; Antonini, Angelo; Margouleff, Claude; Dahl, J. Robert; Belakhlef, Abdelfatihe; Margouleff, Donald; Yee, Archie; Wang, Shaoyin; Tamagnan, Gilles; Neumeyer, John L.; Eidelberg, David.

In: Nuclear Medicine and Biology, Vol. 23, No. 8, 11.1996, p. 999-1004.

Research output: Contribution to journalArticle

Chaly, T, Dhawan, V, Kazumata, K, Antonini, A, Margouleff, C, Dahl, JR, Belakhlef, A, Margouleff, D, Yee, A, Wang, S, Tamagnan, G, Neumeyer, JL & Eidelberg, D 1996, 'Radiosynthesis of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography', Nuclear Medicine and Biology, vol. 23, no. 8, pp. 999-1004. https://doi.org/10.1016/S0969-8051(96)00155-2
Chaly, Thomas ; Dhawan, Vijay ; Kazumata, Ken ; Antonini, Angelo ; Margouleff, Claude ; Dahl, J. Robert ; Belakhlef, Abdelfatihe ; Margouleff, Donald ; Yee, Archie ; Wang, Shaoyin ; Tamagnan, Gilles ; Neumeyer, John L. ; Eidelberg, David. / Radiosynthesis of [18F] N-3-fluoropropyl-2-β-carbomethoxy-3-β-(4-iodophenyl) nortropane and the first human study with positron emission tomography. In: Nuclear Medicine and Biology. 1996 ; Vol. 23, No. 8. pp. 999-1004.
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